{"id":"W2752726198","doi":"10.1371/journal.pone.0182848","title":"Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"National Health and Medical Research Council; Canadian Institutes of Health Research; Australian Government; Alberta Innovates; Agence Nationale de la Recherche; Department of Agriculture, Fisheries and Forestry, Australian Government","keywords":"Spider toxin; IC50; Gating; Venom; Patch clamp; Chemistry; Potency; Pharmacology; Biophysics; Biology; Biochemistry; In vitro; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005436112,0.000230428,0.000281485,0.0002250626,0.00008681291,0.00021236,0.0001387604,0.000233927,0.0003554391],"category_scores_gemma":[0.00006940711,0.00006153736,0.0002202073,0.0001293188,0.0001183306,0.0001324178,0.0001174608,0.0002437843,0.0001286139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001368526,"about_ca_system_score_gemma":0.0001116216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001762342,"about_ca_topic_score_gemma":0.000219225,"domain_scores_codex":[0.9999704,0.000003521664,0.000002811864,0.000007257769,0.000008210134,0.000007665791],"domain_scores_gemma":[0.9999764,0.000003263332,0.00000708028,0.00000153259,0.000004022658,0.000007777116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007803821,0.00002575374,0.0003441522,0.00007667902,0.00000629514,0.0001873189,0.00001182538,0.00006708587,0.9955811,0.00006701502,0.00002315125,0.003531612],"study_design_scores_gemma":[0.0001140052,0.002742934,0.02226008,0.00003900688,0.00009049448,0.004941443,0.00006269188,0.001526233,0.9584978,0.0001501938,0.009560579,0.00001440967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888335,0.00840046,0.001637721,0.000123273,0.00001797258,0.00004851769,0.0001524491,0.00001655873,0.0007695503],"genre_scores_gemma":[0.9886538,0.005617929,0.004014822,0.0001510244,0.00002302059,0.00003331061,0.0004782349,0.000005438471,0.001022424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003554391,"threshold_uncertainty_score":0.001189113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06191671313896277,"score_gpt":0.268160808008735,"score_spread":0.2062440948697722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}