{"id":"W2752781686","doi":"10.1038/tp.2017.188","title":"Accelerated DNA methylation age in adolescent girls: associations with elevated diurnal cortisol and reduced hippocampal volume","year":2017,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute of Mental Health; National Alliance for Research on Schizophrenia and Depression; Canadian Institute for Advanced Research; Canadian Institutes of Health Research; Klingenstein Third Generation Foundation","keywords":"DNA methylation; Methylation; Hippocampal formation; Epigenetics; Internal medicine; Endocrinology; Glucocorticoid; CpG site; Biology; Psychology; Medicine; Genetics; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000224814,0.0001649312,0.0001562305,0.00007309826,0.0002963478,0.0001274262,0.0001365593,0.0001783987,0.00001884956],"category_scores_gemma":[0.00003871148,0.0001626939,0.00004832719,0.0000786798,0.00008009312,0.00002297363,0.00001719445,0.0001547994,0.000003271067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001570056,"about_ca_system_score_gemma":0.0001544117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003485024,"about_ca_topic_score_gemma":0.0007844811,"domain_scores_codex":[0.9988538,0.00007465992,0.0003178802,0.0003384341,0.0002123557,0.0002028474],"domain_scores_gemma":[0.999305,0.000009999621,0.0002313963,0.0002659822,0.0001069705,0.00008064499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002080929,0.0001405326,0.7088143,0.00001595282,0.000060158,0.000001618351,0.00006596288,0.0005086842,0.2868742,0.0002866766,0.00007475769,0.002949082],"study_design_scores_gemma":[0.001660306,0.0001808881,0.9885374,0.00003110199,0.00003021106,0.000001853787,0.00001300587,0.0005769105,0.007095505,0.001292584,0.0003610998,0.0002190758],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937379,0.0006694535,0.002989902,0.001405771,0.0002090767,0.0002872339,0.00004777933,0.0000123128,0.0006406076],"genre_scores_gemma":[0.9962279,0.0001098746,0.002615194,0.00006606066,0.0002492501,0.00001583532,0.0005525278,0.0000238602,0.0001394777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2797787,"threshold_uncertainty_score":0.6634466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03211344016575039,"score_gpt":0.3033336335122247,"score_spread":0.2712201933464743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}