{"id":"W2752818287","doi":"10.1182/blood.v118.21.523.523","title":"Thymic Retention of CD4+CD25hi+FoxP3+ T Regulatory (Treg) Cells Is Responsible for Peripheral Treg Deficiency and Platelet and Megakaryocyte Destruction in Active Immune Thrombocytopenia (ITP)","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; St. Michael's Hospital","funders":"","keywords":"FOXP3; Megakaryocyte; Immunology; Platelet; Immune system; IL-2 receptor; Bone marrow; Regulatory T cell; Splenocyte; Adoptive cell transfer; Medicine; Biology; T cell; Stem cell; Cell biology; Haematopoiesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001487078,0.0002734139,0.0002794666,0.0002752516,0.0001512868,0.000247456,0.0001972377,0.0002795306,0.002253524],"category_scores_gemma":[0.0001507352,0.0001764752,0.0002319578,0.00006857284,0.000281117,0.0001412391,0.0001694625,0.001031235,0.0004861791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000111224,"about_ca_system_score_gemma":0.000139624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002586165,"about_ca_topic_score_gemma":0.0003781857,"domain_scores_codex":[0.9998229,0.00002401546,0.0000146414,0.00004043638,0.00003652638,0.00006151463],"domain_scores_gemma":[0.9997287,0.00002196793,0.00006758414,0.00002831097,0.00001798136,0.0001353827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003683297,0.00007915643,0.00132178,0.00003997002,0.000007321788,0.0003260763,0.00002138996,0.00004763563,0.9953356,0.00009396527,0.00009863792,0.002260125],"study_design_scores_gemma":[0.000498671,0.002675573,0.1117221,0.00007796112,0.0001545948,0.007748708,0.0002668787,0.002944398,0.8669874,0.0004287347,0.006469594,0.000025315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962322,0.001022287,0.001176618,0.00007249241,0.00004488648,0.0000247843,0.0001889628,0.0001017221,0.00113595],"genre_scores_gemma":[0.9974601,0.0002501752,0.0003153422,0.00005041237,0.00002749895,0.00002601241,0.0001687931,0.00001771241,0.00168393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002253524,"threshold_uncertainty_score":0.007538795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02173827785737992,"score_gpt":0.2402376312136202,"score_spread":0.2184993533562402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}