{"id":"W2752960428","doi":"10.1002/anie.201707375","title":"Catalytic Enantioselective Synthesis of Highly Functionalized Difluoromethylated Cyclopropanes","year":2017,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre in Green Chemistry and Catalysis","funders":"Agence Nationale de la Recherche","keywords":"Cyclopropanation; Enantioselective synthesis; Catalysis; Rhodium; Nitro; Ketone; Chemistry; Organic chemistry; Combinatorial chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002506449,0.0008411795,0.0002892621,0.0003366981,0.0001606228,0.0002145921,0.0004318974,0.00037463,0.003689711],"category_scores_gemma":[0.0002380081,0.0001932863,0.0002106594,0.0002131213,0.0001685743,0.0003046975,0.0003931104,0.0008077106,0.00126275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002876938,"about_ca_system_score_gemma":0.0003868916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005636423,"about_ca_topic_score_gemma":0.001002624,"domain_scores_codex":[0.999804,0.00002767003,0.00001459961,0.00002798261,0.00004732675,0.00007849166],"domain_scores_gemma":[0.9999305,0.00001322635,0.00001368654,0.00001013488,0.00001421534,0.00001819207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001131546,0.00004875577,0.0001009698,0.0002357728,0.00001964484,0.0006062769,0.00007532468,0.0005215163,0.9861994,0.001778715,0.0006876197,0.009613005],"study_design_scores_gemma":[0.00003685922,0.0001554094,0.0004328706,0.00001915949,0.00001628054,0.0003119887,0.00002008658,0.0006835989,0.9883437,0.0001696069,0.009793943,0.00001648138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.90407,0.007020061,0.0379199,0.0007224407,0.0004704106,0.0003653569,0.002731228,0.0006981844,0.04600238],"genre_scores_gemma":[0.9749364,0.003366848,0.01329327,0.000146867,0.0000501068,0.0001046175,0.0007969781,0.00008000981,0.007224877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003689711,"threshold_uncertainty_score":0.01234329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05529175357341832,"score_gpt":0.3803534185152376,"score_spread":0.3250616649418193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}