{"id":"W2753016068","doi":"10.1158/1078-0432.ccr-17-1259","title":"Chemogenomic Landscape of <i>RUNX1</i> -mutated AML Reveals Importance of <i>RUNX1</i> Allele Dosage in Genetics and Glucocorticoid Sensitivity","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont; Institute for Research in Immunology and Cancer","funders":"","keywords":"RUNX1; Biology; Myeloid leukemia; Leukemia; Myeloid; Allele; Pharmacogenomics; Glucocorticoid receptor; Cancer research; Gene; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008237319,0.0001559044,0.000186273,0.0002896164,0.00009810511,0.0002216549,0.0001201173,0.0002126236,0.001437897],"category_scores_gemma":[0.0001597886,0.00008138286,0.0001407578,0.0002032926,0.0001909679,0.00007442282,0.0001211838,0.0002251551,0.0002572391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000206065,"about_ca_system_score_gemma":0.0001173836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00074193,"about_ca_topic_score_gemma":0.001055024,"domain_scores_codex":[0.9999092,0.000009231076,0.000006175563,0.0000243206,0.00003403635,0.00001696935],"domain_scores_gemma":[0.999915,0.00001753803,0.00003071212,0.00001014892,0.000009550825,0.00001700474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001318131,0.00001126108,0.00498697,0.00001302556,0.00000587463,0.00005588997,0.00001352195,0.0001126115,0.992749,0.00002919603,0.00003018884,0.001860578],"study_design_scores_gemma":[0.00001358661,0.0004780223,0.203548,0.000006200131,0.00005932832,0.001541853,0.0001142468,0.002151024,0.7897814,0.000136476,0.002160825,0.000008980382],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975144,0.0003346505,0.0007943701,0.00005033868,0.000002505386,0.00001367045,0.000711841,0.00004246148,0.0005358016],"genre_scores_gemma":[0.9979458,0.0002121642,0.0006664016,0.00003417254,0.000002916167,0.00001293515,0.0007085932,0.00001685674,0.0004001244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001437897,"threshold_uncertainty_score":0.004810274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1365045459684899,"score_gpt":0.4825954670593621,"score_spread":0.3460909210908721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}