{"id":"W2753016068","doi":"10.1158/1078-0432.ccr-17-1259","title":"Chemogenomic Landscape of <i>RUNX1</i> -mutated AML Reveals Importance of <i>RUNX1</i> Allele Dosage in Genetics and Glucocorticoid Sensitivity","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont; Institute for Research in Immunology and Cancer","funders":"","keywords":"RUNX1; Biology; Myeloid leukemia; Leukemia; Myeloid; Allele; Pharmacogenomics; Glucocorticoid receptor; Cancer research; Gene; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008281244,0.0002319488,0.001265668,0.0002471747,0.000142626,0.00004259384,0.0005146236,0.0003680904,0.0001984592],"category_scores_gemma":[0.003544426,0.0002070572,0.0001840795,0.0003553266,0.001773249,0.0001153473,0.0008733381,0.001647636,0.00002554796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002494224,"about_ca_system_score_gemma":0.001594384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00133834,"about_ca_topic_score_gemma":0.001241019,"domain_scores_codex":[0.9951603,0.00065003,0.001386978,0.000821045,0.001084922,0.0008967132],"domain_scores_gemma":[0.9949542,0.001618839,0.0004997368,0.001737137,0.0007431516,0.0004469123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002199004,0.000299315,0.8776708,0.0006213715,0.0001151348,0.0003104845,0.0001169913,0.00001181776,0.1073731,0.00002606965,0.002848578,0.008407347],"study_design_scores_gemma":[0.00702828,0.0007761054,0.9533734,0.000336602,0.00004971827,0.00003177834,0.0001365851,0.001783451,0.03495165,0.000174014,0.001150181,0.0002082434],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911474,0.00287076,0.000006784742,0.002330542,0.00008343306,0.00136139,0.0001029273,0.00001459148,0.002082144],"genre_scores_gemma":[0.9887331,0.009591804,0.000375613,0.0002205581,0.0002447717,0.00005807085,0.00002479466,0.00005694646,0.0006943849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07570256,"threshold_uncertainty_score":0.8443548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1365045459684899,"score_gpt":0.4825954670593621,"score_spread":0.3460909210908721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}