{"id":"W2753127471","doi":"10.1158/1078-0432.ccr-16-3079","title":"Challenges and Opportunities in Adapting Clinical Trial Design for Immunotherapies","year":2017,"lang":"en","type":"editorial","venue":"Clinical Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Clinical trial; Medicine; Immunotherapy; Cancer; Cancer immunotherapy; Pillar; Clinical study design; Biomarker; Oncology; Intensive care medicine; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.2799775,0.002391755,0.004471563,0.003263766,0.001617537,0.01124053,0.006999296,0.01796789,0.0073523],"category_scores_gemma":[0.43138,0.001452812,0.004500262,0.002336707,0.009298062,0.01130869,0.003435827,0.04787794,0.003787962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006405657,"about_ca_system_score_gemma":0.0114859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000873972,"about_ca_topic_score_gemma":0.00208341,"domain_scores_codex":[0.8389977,0.1106971,0.01661993,0.005423716,0.0268308,0.001430784],"domain_scores_gemma":[0.310973,0.5967405,0.009875298,0.01359732,0.05928596,0.009528039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004413369,0.00008092739,0.0001905066,0.003394755,0.0003898625,0.0002224925,0.0002814238,0.001274552,0.0002022869,0.02734035,0.7645689,0.2016126],"study_design_scores_gemma":[0.0006216436,0.0002947831,0.0003879663,0.005092589,0.0003143782,0.0003015826,0.0001441252,0.002409728,0.0002244504,0.05013986,0.939965,0.0001041407],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.0002799185,0.07358148,0.02419289,0.3907258,0.5062658,0.0005731002,0.0001405421,0.0004262497,0.00381419],"genre_scores_gemma":[0.004382882,0.04383965,0.02385191,0.219432,0.7024919,0.000992298,0.00008672671,0.0003260169,0.004596687],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.2799775,"threshold_uncertainty_score":0.887916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7863942232871721,"score_gpt":0.6191165422598202,"score_spread":0.167277681027352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}