{"id":"W2753139577","doi":"10.1080/09205063.2017.1374032","title":"Self-assembled nanoparticles made from a new PEGylated poly(aspartic acid) graft copolymer for intravaginal delivery of poorly water-soluble drugs","year":2017,"lang":"en","type":"article","venue":"Journal of Biomaterials Science Polymer Edition","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Science and Engineering Research Council; Natural Sciences and Engineering Research Council of Canada; Research Manitoba","keywords":"Dynamic light scattering; Nanocarriers; Zeta potential; PEG ratio; Copolymer; Nuclear chemistry; Chemistry; Amphiphile; Nanoparticle; Ethylene glycol; Aspartic acid; Drug delivery; In vitro; Biophysics; In vivo; Polymer chemistry; Materials science; Polymer; Nanotechnology; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001099893,0.0003124561,0.0001584383,0.0001615104,0.00008186544,0.0001795008,0.0001228506,0.0002942962,0.0003281845],"category_scores_gemma":[0.0001004467,0.0001521295,0.0001788558,0.00009577088,0.0001198532,0.0002378937,0.0001439044,0.0002851172,0.0002325438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000190775,"about_ca_system_score_gemma":0.000138746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002889407,"about_ca_topic_score_gemma":0.0004355106,"domain_scores_codex":[0.9999392,0.000006600447,0.000005674432,0.00001680466,0.00002254267,0.000009091468],"domain_scores_gemma":[0.9999379,0.000007312753,0.00002272997,0.000003791245,0.00001141873,0.00001674394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001693847,0.000006108727,0.00002760038,0.00002113891,0.00000200211,0.00002608164,0.000003674383,0.00008810987,0.9987234,0.00004065037,0.000008804649,0.001035389],"study_design_scores_gemma":[0.00001151518,0.0001791798,0.0006910516,0.000003075379,0.00001131569,0.0001688958,0.000003945594,0.001285738,0.995903,0.00002126949,0.001716053,0.000005052911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9743696,0.003236047,0.01995599,0.0001140619,0.00007781727,0.00007528037,0.0001440225,0.0001794074,0.001847738],"genre_scores_gemma":[0.9825253,0.001274267,0.0137051,0.00005596893,0.00001908119,0.00003333387,0.0001316887,0.00002305981,0.002232091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003281845,"threshold_uncertainty_score":0.001384199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05436064019005895,"score_gpt":0.3858656982393284,"score_spread":0.3315050580492694,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}