{"id":"W2753212558","doi":"10.1016/j.clml.2017.07.213","title":"Global Pivotal Phase 2 Trial of the CD19-Targeted Therapy CTL019 In Adult Patients with Relapsed or Refractory (R/R) Diffuse Large B-Cell Lymphoma (DLBCL)—An Interim Analysis","year":2017,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; Université de Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Interim; Diffuse large B-cell lymphoma; Oncology; Interim analysis; Internal medicine; Clinical trial; Chimeric antigen receptor; Refractory (planetary science); Phases of clinical research; Medicine; Follicular lymphoma; Lymphoma; Biology; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003332528,0.001830361,0.002518288,0.0002996789,0.0003347601,0.001885896,0.001013523,0.001365197,0.004316788],"category_scores_gemma":[0.001661057,0.000512169,0.002516428,0.0003623294,0.001132804,0.001503172,0.0006146881,0.004239401,0.001564719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001139836,"about_ca_system_score_gemma":0.001879884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008611205,"about_ca_topic_score_gemma":0.003701437,"domain_scores_codex":[0.999348,0.0003443851,0.00002155986,0.00008760126,0.00004833576,0.0001501095],"domain_scores_gemma":[0.9990426,0.0002464833,0.0001343363,0.00009692492,0.0000638473,0.0004157789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7501442,0.008471549,0.007861417,0.001550175,0.005848302,0.0004517209,0.0003319483,0.006873856,0.01370418,0.001563532,0.04696787,0.1562312],"study_design_scores_gemma":[0.8203355,0.1328394,0.0173411,0.0001910233,0.002782896,0.0006062587,0.0001393812,0.002520755,0.00205174,0.002513864,0.01860598,0.00007220638],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9379078,0.01812924,0.003386597,0.008943494,0.001428794,0.003180907,0.01178962,0.0007096615,0.01452397],"genre_scores_gemma":[0.937161,0.007245721,0.006140436,0.01328947,0.0007459142,0.003134901,0.02184775,0.0002805075,0.01015417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004316788,"threshold_uncertainty_score":0.01762432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03986480031442897,"score_gpt":0.3797167450211926,"score_spread":0.3398519447067636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}