{"id":"W2753213070","doi":"10.1016/j.molmet.2017.08.012","title":"Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants","year":2017,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Birth, Development, and Health","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Nutrition Obesity Research Center, University of North Carolina; National Cancer Institute; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Georgia Clinical and Translational Science Alliance; American Heart Association; Dunspaugh-Dalton Foundation","keywords":"Endocrinology; Internal medicine; DNA methylation; Adipogenesis; Beta oxidation; AMPK; Mesenchymal stem cell; Biology; Lipid metabolism; Umbilical cord; Fatty acid; Fatty acid metabolism; Medicine; Adipose tissue; Metabolism; Biochemistry; Cell biology; Immunology; Gene; Gene expression; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005898639,0.000217654,0.0005111096,0.0001584499,0.0003156945,0.0001194012,0.0001639674,0.0001702648,0.00003769284],"category_scores_gemma":[0.00005973093,0.0002126579,0.00006286344,0.00008139644,0.00007438492,0.0002693471,0.0001281936,0.0002944872,0.00001539806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008983842,"about_ca_system_score_gemma":0.0001051646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002786033,"about_ca_topic_score_gemma":0.0007623656,"domain_scores_codex":[0.9982916,0.0002033806,0.0003390514,0.0004097756,0.0004177344,0.0003385194],"domain_scores_gemma":[0.9988737,0.00001720168,0.0003684056,0.0004515449,0.00009318015,0.0001959834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004150062,0.00008731111,0.1864178,0.00002814167,0.00008363677,0.00004940565,0.0004426802,5.478325e-7,0.8094002,0.0008004988,0.00002265193,0.0026256],"study_design_scores_gemma":[0.001237461,0.00001151074,0.5506257,0.00004053269,0.00005262049,0.000001459378,0.00001146177,0.00003072723,0.4466468,0.001197754,0.00003756629,0.0001063468],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971207,0.0002907786,0.000888098,0.0004715062,0.0002937653,0.0004095499,0.00002682045,0.00004025361,0.0004585454],"genre_scores_gemma":[0.9976718,0.0009202062,0.000887129,0.0003304271,0.00007427368,0.00001355698,0.00004522848,0.00002719597,0.00003018846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3642079,"threshold_uncertainty_score":0.8671936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02181390149617946,"score_gpt":0.2927957616578997,"score_spread":0.2709818601617202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}