{"id":"W2753213070","doi":"10.1016/j.molmet.2017.08.012","title":"Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants","year":2017,"lang":"en","type":"article","venue":"Molecular Metabolism","topic":"Birth, Development, and Health","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Nutrition Obesity Research Center, University of North Carolina; National Cancer Institute; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Georgia Clinical and Translational Science Alliance; American Heart Association; Dunspaugh-Dalton Foundation","keywords":"Endocrinology; Internal medicine; DNA methylation; Adipogenesis; Beta oxidation; AMPK; Mesenchymal stem cell; Biology; Lipid metabolism; Umbilical cord; Fatty acid; Fatty acid metabolism; Medicine; Adipose tissue; Metabolism; Biochemistry; Cell biology; Immunology; Gene; Gene expression; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001186043,0.000137096,0.0001367095,0.0002405362,0.00009574577,0.0001722911,0.00006630913,0.0001156628,0.001152826],"category_scores_gemma":[0.0002428424,0.00009274461,0.0001093289,0.0001774019,0.0001121541,0.00005670244,0.0001423475,0.0001583821,0.0001951454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006749305,"about_ca_system_score_gemma":0.00009639942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005457277,"about_ca_topic_score_gemma":0.0006500373,"domain_scores_codex":[0.9999156,0.00001408732,0.000009356219,0.00002020454,0.00002820111,0.00001255591],"domain_scores_gemma":[0.9999198,0.0000155183,0.0000318015,0.000007368456,0.00001349236,0.00001203827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008131524,0.00003613161,0.04409955,0.0000802574,0.00003047349,0.0003360981,0.000277192,0.00006095782,0.9443693,0.00006574463,0.00005691905,0.009774136],"study_design_scores_gemma":[0.00002233121,0.0008636431,0.6218522,0.0000275685,0.00009298577,0.002444322,0.0006398362,0.0005297574,0.3706517,0.0001041144,0.002759481,0.00001217333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981889,0.0006378442,0.0006457344,0.00002306955,0.000004926098,0.000006396872,0.0002468791,0.000009655958,0.0002366504],"genre_scores_gemma":[0.9978905,0.0005769875,0.0005346584,0.00002153671,0.000004341212,0.00002114839,0.0003940118,0.000006035648,0.0005508047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001152826,"threshold_uncertainty_score":0.00385654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02181390149617946,"score_gpt":0.2927957616578997,"score_spread":0.2709818601617202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}