{"id":"W2753305389","doi":"10.1101/gad.300566.117","title":"Progressive polarity loss and luminal collapse disrupt tissue organization in carcinoma","year":2017,"lang":"en","type":"article","venue":"Genes & Development","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canada Foundation for Innovation; Fondation du cancer du sein du Québec; Cancer Research Society; McGill University","keywords":"Biology; Cell polarity; RHOA; Epithelial polarity; Lumen (anatomy); Polarity (international relations); Cell biology; Epithelium; Cell; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001150439,0.0001086269,0.0001879943,0.00005380365,0.000207728,0.00005464924,0.00007100353,0.00004946845,0.00008166076],"category_scores_gemma":[0.00005068954,0.00009706066,0.000008545113,0.00009616835,0.00006738985,0.000061996,0.0001175994,0.00005771075,0.00001375967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001214184,"about_ca_system_score_gemma":0.0003769532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002006197,"about_ca_topic_score_gemma":0.0002755255,"domain_scores_codex":[0.9992562,0.00001185514,0.0001674562,0.0002246545,0.0001567382,0.000183112],"domain_scores_gemma":[0.9994512,0.000005193515,0.00008778264,0.0002171078,0.0001302322,0.0001085245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004720132,0.00006842595,0.8627716,0.0001051674,0.00002059679,0.0003075566,0.001366288,1.731261e-7,0.004756641,0.0000181119,0.000109114,0.1304291],"study_design_scores_gemma":[0.0009110059,0.00003788455,0.8660391,0.00005546609,0.00002790268,0.0001242474,0.0001216832,0.000001533405,0.1075917,0.00000771192,0.02497309,0.0001086378],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963992,0.002065306,0.00004908277,0.0006921649,0.0001906475,0.0003472124,0.000004558953,0.00001166393,0.0002401715],"genre_scores_gemma":[0.9950736,0.0001441879,0.003991624,0.00006625342,0.0001045995,0.00002091625,0.00003376062,0.00001425867,0.000550768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1303205,"threshold_uncertainty_score":0.3958019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01575955138539147,"score_gpt":0.2896480952006346,"score_spread":0.2738885438152431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}