{"id":"W2753305389","doi":"10.1101/gad.300566.117","title":"Progressive polarity loss and luminal collapse disrupt tissue organization in carcinoma","year":2017,"lang":"en","type":"article","venue":"Genes & Development","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canada Foundation for Innovation; Fondation du cancer du sein du Québec; Cancer Research Society; McGill University","keywords":"Biology; Cell polarity; RHOA; Epithelial polarity; Lumen (anatomy); Polarity (international relations); Cell biology; Epithelium; Cell; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001117964,0.0001748437,0.0002105457,0.0003511523,0.0002255376,0.0004521753,0.0001393643,0.0002932517,0.0009913406],"category_scores_gemma":[0.0001078425,0.0001970529,0.0002550409,0.0001555564,0.0002862943,0.0002199869,0.0003401894,0.0007117437,0.0003371043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002580239,"about_ca_system_score_gemma":0.000253739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000513343,"about_ca_topic_score_gemma":0.0008973663,"domain_scores_codex":[0.9998288,0.00002831942,0.00001229472,0.00002796655,0.00005125477,0.000051349],"domain_scores_gemma":[0.9998938,0.00001166285,0.00003548419,0.00001745124,0.000007067054,0.00003450215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003420454,0.00002687422,0.0003822694,0.00001418571,0.000004956901,0.00007470331,0.00001220585,0.00004947217,0.9980274,0.0002057391,0.00004378918,0.001124153],"study_design_scores_gemma":[0.0000137541,0.0003041849,0.01630813,0.00000746974,0.00001751505,0.001317822,0.00007745106,0.0008742235,0.9773037,0.0001640207,0.003604768,0.000006939295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935893,0.001784779,0.002563615,0.0001607495,0.00002770298,0.00003351255,0.0002312092,0.0001259743,0.001483189],"genre_scores_gemma":[0.9963363,0.0008978629,0.001017926,0.00007620938,0.000006086813,0.00002113261,0.000221146,0.00001518299,0.001408111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009913406,"threshold_uncertainty_score":0.003316402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01575955138539147,"score_gpt":0.2896480952006346,"score_spread":0.2738885438152431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}