{"id":"W2753321278","doi":"10.1186/s13054-017-1823-x","title":"A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome","year":2017,"lang":"en","type":"article","venue":"Critical Care","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":631,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia; Hôpital Charles-Le Moyne; Nova Scotia Health Authority; Dalhousie University; St. Paul's Hospital","funders":"Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; McGill University Health Centre; University of South Carolina; University of California, Davis; McGill University; Thomas Jefferson University; University of Pennsylvania; Tulane University; Wake Forest University; Northwestern University; GlaxoSmithKline","keywords":"Medicine; ARDS; Placebo; Angiotensin II; Dosing; Angiotensin-converting enzyme 2; Renin–angiotensin system; Pharmacodynamics; Angiotensin-converting enzyme; Internal medicine; Pharmacokinetics; Pharmacology; Anesthesia; Lung; Receptor; Blood pressure; Pathology; Coronavirus disease 2019 (COVID-19); Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007694376,0.0002494495,0.001290223,0.0001154805,0.0003035853,0.00004922802,0.0002906183,0.0001894006,0.00001839254],"category_scores_gemma":[0.005790199,0.0002118713,0.0003905015,0.00007876914,0.0009118335,0.0001095669,0.0003046216,0.000465256,0.00002200824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001118712,"about_ca_system_score_gemma":0.0001071796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001460425,"about_ca_topic_score_gemma":0.00008291173,"domain_scores_codex":[0.9970338,0.0002520657,0.001248269,0.0005520612,0.0004328032,0.0004810129],"domain_scores_gemma":[0.9972807,0.0004811321,0.0002374275,0.001217277,0.0005449961,0.000238459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02981483,0.002161221,0.9216897,0.001254565,0.0007339317,0.01655407,0.001836489,2.440673e-7,0.008240984,0.003366535,0.007120458,0.007226988],"study_design_scores_gemma":[0.04674307,0.008353955,0.9395678,0.001945806,0.0005589202,0.0001720474,0.0004255423,0.000009376535,0.001146801,0.0001680795,0.0005568079,0.0003517973],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930378,0.001032963,0.000006141212,0.001529048,0.002106166,0.0007046169,0.00002788253,0.00004605805,0.001509386],"genre_scores_gemma":[0.9990598,0.00000896793,0.0001566737,0.0001873362,0.0003787672,0.00002579711,0.00001183782,0.00004086484,0.000129985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01787811,"threshold_uncertainty_score":0.8639862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1572324686640298,"score_gpt":0.4466520244700409,"score_spread":0.2894195558060111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}