{"id":"W2753321278","doi":"10.1186/s13054-017-1823-x","title":"A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome","year":2017,"lang":"en","type":"article","venue":"Critical Care","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":631,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia; Hôpital Charles-Le Moyne; Nova Scotia Health Authority; Dalhousie University; St. Paul's Hospital","funders":"Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval; McGill University Health Centre; University of South Carolina; University of California, Davis; McGill University; Thomas Jefferson University; University of Pennsylvania; Tulane University; Wake Forest University; Northwestern University; GlaxoSmithKline","keywords":"Medicine; ARDS; Placebo; Angiotensin II; Dosing; Angiotensin-converting enzyme 2; Renin–angiotensin system; Pharmacodynamics; Angiotensin-converting enzyme; Internal medicine; Pharmacokinetics; Pharmacology; Anesthesia; Lung; Receptor; Blood pressure; Pathology; Coronavirus disease 2019 (COVID-19); Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002326188,0.002235316,0.00219676,0.0004772946,0.0004315231,0.0009893483,0.00098999,0.001721077,0.004946817],"category_scores_gemma":[0.001649665,0.0005371115,0.001212676,0.00034011,0.001561547,0.001060993,0.0005542714,0.003629478,0.001043022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005531397,"about_ca_system_score_gemma":0.00161448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005016575,"about_ca_topic_score_gemma":0.0007574636,"domain_scores_codex":[0.9992316,0.0003917688,0.000044284,0.0001163508,0.00004806212,0.000167955],"domain_scores_gemma":[0.998396,0.0004142053,0.0002029861,0.0001635336,0.0001005609,0.0007226426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9024316,0.05625733,0.001155262,0.000411504,0.0003939118,0.0002270362,0.0001310461,0.000581568,0.01620137,0.0001506109,0.001226517,0.02083224],"study_design_scores_gemma":[0.5879647,0.4088476,0.001480969,0.00001056466,0.00007716261,0.00005411739,0.00001640857,0.0001884942,0.0008237478,0.0000609413,0.0004665616,0.000008738079],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891638,0.001098087,0.0006896018,0.0006393254,0.000350498,0.00573801,0.0007312255,0.00012163,0.00146794],"genre_scores_gemma":[0.9868339,0.0008149713,0.001726247,0.001059924,0.0004253101,0.006099775,0.001294932,0.00001770244,0.001727284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004946817,"threshold_uncertainty_score":0.01654881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1572324686640298,"score_gpt":0.4466520244700409,"score_spread":0.2894195558060111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}