{"id":"W2753475743","doi":"10.1111/bcp.13423","title":"Dose‐dependent acute liver injury with hypersensitivity features in humans due to a novel microsomal prostaglandin E synthase 1 inhibitor","year":2017,"lang":"en","type":"article","venue":"British Journal of Clinical Pharmacology","topic":"Drug-Induced Hepatotoxicity and Protection","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Eli Lilly and Company","keywords":"Tolerability; Medicine; Pharmacology; Liver injury; Adverse effect; Dosing; Autoimmune hepatitis; Nimesulide; Pharmacodynamics; Pharmacokinetics; Toxicity; Placebo; Internal medicine; Hepatitis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001032033,0.0006865957,0.0009165927,0.0002290701,0.0003194413,0.0003129164,0.000277422,0.0005458624,0.001848492],"category_scores_gemma":[0.0006245206,0.0003586395,0.0004711513,0.0001621308,0.000481734,0.0002347411,0.0001885776,0.0009323179,0.000382527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004074948,"about_ca_system_score_gemma":0.0003830869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003092339,"about_ca_topic_score_gemma":0.000588551,"domain_scores_codex":[0.9995545,0.0002574966,0.00002955877,0.0000505563,0.0000583531,0.00004954593],"domain_scores_gemma":[0.9996817,0.00007346212,0.0000990792,0.0000504027,0.00002189833,0.00007345947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"case_report","study_design_scores_codex":[0.1614146,0.02089358,0.01944741,0.000815427,0.0005955162,0.001866391,0.0002350312,0.0009027495,0.7227381,0.0002579873,0.001256743,0.06957643],"study_design_scores_gemma":[0.01862461,0.741984,0.08677115,0.00004359419,0.0005081402,0.004575594,0.000117668,0.002281227,0.1417739,0.0002307259,0.003044941,0.00004443392],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971452,0.0009685255,0.0007965217,0.00006988779,0.00002503763,0.0003517999,0.000122829,0.00003557533,0.0004845367],"genre_scores_gemma":[0.9981173,0.0004589872,0.0004996408,0.0001144401,0.00003463638,0.0001763457,0.0001941149,0.000005373263,0.0003991064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001848492,"threshold_uncertainty_score":0.006183803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1260799895779003,"score_gpt":0.4713106002948118,"score_spread":0.3452306107169114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}