{"id":"W2753561811","doi":"10.1177/1352458517728811","title":"Unexpected additive effects of minocycline and hydroxychloroquine in models of multiple sclerosis: Prospective combination treatment for progressive disease?","year":2017,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"U.S. Food and Drug Administration","keywords":"Minocycline; Hydroxychloroquine; Multiple sclerosis; Medicine; Experimental autoimmune encephalomyelitis; Pharmacology; Neurotoxicity; Microglia; Toxicity; Immunology; Internal medicine; Disease; Inflammation; Chemistry; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008042867,0.00055095,0.001087634,0.0004278329,0.0002353873,0.0005390401,0.0005338094,0.0004913608,0.00139552],"category_scores_gemma":[0.000220582,0.0001463637,0.000518283,0.00027704,0.0003833807,0.0004346844,0.0002486769,0.0008995399,0.0002115378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000247543,"about_ca_system_score_gemma":0.0004358906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003119688,"about_ca_topic_score_gemma":0.001857025,"domain_scores_codex":[0.9996685,0.0001154763,0.00003366676,0.00005348635,0.00006894787,0.00005981429],"domain_scores_gemma":[0.9997733,0.00003791463,0.00006028061,0.00002598726,0.00003662982,0.00006590802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01978,0.008084017,0.002367562,0.001774998,0.0004914341,0.0003426489,0.0001618534,0.0005193812,0.8664168,0.0004237716,0.0005058948,0.09913158],"study_design_scores_gemma":[0.006217142,0.2856983,0.02280631,0.0003523497,0.002207924,0.001181925,0.0002530436,0.001628525,0.659937,0.0005771019,0.01907782,0.00006264128],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9616441,0.03315008,0.002085483,0.0004151959,0.0001931789,0.0004611755,0.0001664639,0.00006321367,0.001821142],"genre_scores_gemma":[0.9802838,0.01306956,0.00417728,0.0001687992,0.0001549834,0.0002466803,0.0001770672,0.00001282279,0.001708969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00139552,"threshold_uncertainty_score":0.004668474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09880776252245432,"score_gpt":0.3255740117319261,"score_spread":0.2267662492094718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}