{"id":"W2753561811","doi":"10.1177/1352458517728811","title":"Unexpected additive effects of minocycline and hydroxychloroquine in models of multiple sclerosis: Prospective combination treatment for progressive disease?","year":2017,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"U.S. Food and Drug Administration","keywords":"Minocycline; Hydroxychloroquine; Multiple sclerosis; Medicine; Experimental autoimmune encephalomyelitis; Pharmacology; Neurotoxicity; Microglia; Toxicity; Immunology; Internal medicine; Disease; Inflammation; Chemistry; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00047439,0.000473361,0.001287992,0.0005018964,0.0006100022,0.0001000893,0.0003049846,0.0001538685,0.00001341147],"category_scores_gemma":[0.005403999,0.0003798185,0.0003806423,0.0001999009,0.0007906907,0.0006206317,0.000204922,0.0003318568,9.090555e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004765794,"about_ca_system_score_gemma":0.0002098227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002420083,"about_ca_topic_score_gemma":0.0002026328,"domain_scores_codex":[0.9967747,0.0001751448,0.001009105,0.0006189654,0.0007657463,0.000656375],"domain_scores_gemma":[0.9952298,0.001222068,0.001223363,0.0006413601,0.001203598,0.000479751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01076969,0.006280025,0.6923904,0.001057449,0.001302473,0.00004630093,0.004038926,0.0002569754,0.2269276,0.0000781792,0.0001782273,0.05667375],"study_design_scores_gemma":[0.03652214,0.002353925,0.8197338,0.003820625,0.0002607824,0.000007483488,0.0003743984,0.03418855,0.1021919,0.0002789737,0.00001183158,0.0002555381],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907958,0.002756435,0.000513439,0.000564227,0.0001891143,0.004614332,0.0004845909,0.00003049582,0.00005156365],"genre_scores_gemma":[0.9914176,0.003873242,0.003265993,0.0000164487,0.0001886541,0.00105311,0.00006989697,0.0000644424,0.00005056303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1273434,"threshold_uncertainty_score":0.9998654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09880776252245432,"score_gpt":0.3255740117319261,"score_spread":0.2267662492094718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}