{"id":"W2753741461","doi":"10.1158/0008-5472.can-17-0707","title":"CD73 Promotes Resistance to HER2/ErbB2 Antibody Therapy","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institut du Savoir Montfort; Centre Hospitalier de l’Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fonds De La Recherche Scientifique - FNRS; National Health and Medical Research Council; Breast Cancer Research Foundation; Susan G. Komen for the Cure","keywords":"Trastuzumab; Cancer research; Immune system; Stromal cell; Antibody; Cancer cell; Medicine; Monoclonal antibody; Breast cancer; Cancer; Immunology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001146664,0.000115225,0.0001840848,0.0002235391,0.0001232968,0.0004297626,0.00007032036,0.0001568126,0.001874582],"category_scores_gemma":[0.0001280126,0.00006718367,0.0001149039,0.0001828524,0.0001228467,0.00008559933,0.0001056117,0.0003980074,0.0003891826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003603605,"about_ca_system_score_gemma":0.0001793781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006675645,"about_ca_topic_score_gemma":0.0008883741,"domain_scores_codex":[0.9998782,0.00001628487,0.000004160948,0.00001064108,0.00003384052,0.00005691762],"domain_scores_gemma":[0.9999435,0.00001203808,0.00001250693,0.000005302184,0.000007436119,0.00001925331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008598439,0.0003411383,0.004851206,0.00005150856,0.00002088456,0.0003926733,0.00002201978,0.0002174682,0.9743328,0.0002900294,0.001085022,0.01753533],"study_design_scores_gemma":[0.0002612427,0.002632398,0.1190491,0.00003402141,0.0001048573,0.002695294,0.0001737456,0.004824427,0.8468492,0.0003690157,0.02299337,0.0000131895],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936795,0.002900527,0.0003053925,0.0001457337,0.00002962285,0.00001856019,0.0000943421,0.00004798012,0.002778366],"genre_scores_gemma":[0.9981287,0.0005332473,0.0001040162,0.0000338318,0.000009122932,0.000006315752,0.00008694348,0.000003947618,0.001093879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001874582,"threshold_uncertainty_score":0.006271124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1319793339646701,"score_gpt":0.4944404438853889,"score_spread":0.3624611099207188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}