{"id":"W2753763597","doi":"10.1101/182691","title":"The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Ministerio de Ciencia e Innovación; National Institutes of Health; Michael Smith Health Research BC","keywords":"Corepressor; HDAC1; Gene; Histone; Histone deacetylase; Transcriptional regulation; Downregulation and upregulation; Regulation of gene expression; Transcription (linguistics); HDAC10; Repressor; Biology; Gene expression; Transcription factor; HDAC4; Hypoxia (environmental); HDAC11; Cell biology; Chemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001971858,0.0003077472,0.0003702214,0.0001962661,0.0002559388,0.0004786644,0.0002265963,0.0002846281,0.00278868],"category_scores_gemma":[0.0002692452,0.0002506755,0.0003389704,0.0001863602,0.0003173747,0.0001904798,0.0004278625,0.0005184663,0.001671215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003594535,"about_ca_system_score_gemma":0.000380832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009759426,"about_ca_topic_score_gemma":0.00124214,"domain_scores_codex":[0.9998348,0.0000180664,0.00001493851,0.00004641812,0.00004932186,0.00003646021],"domain_scores_gemma":[0.9997243,0.00003199396,0.00006633369,0.00005671528,0.00003181415,0.00008876514],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001594966,0.000009152215,0.0006710675,0.00002686433,0.000005684415,0.00005291804,0.000009531222,0.00004700958,0.9979863,0.00009633347,0.0001242295,0.0008113593],"study_design_scores_gemma":[0.00003594008,0.00006931637,0.05292634,0.00001408059,0.00001275754,0.0003934826,0.0000537858,0.002828495,0.938894,0.0003106375,0.004451927,0.000009227325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843214,0.00202859,0.00814323,0.0002323938,0.0001130324,0.00002248301,0.002232784,0.0004992987,0.002406846],"genre_scores_gemma":[0.9926193,0.0002179899,0.00177834,0.00006259941,0.00001633469,0.00001187078,0.002476076,0.0001487702,0.002668665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00278868,"threshold_uncertainty_score":0.009329081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04247264150298288,"score_gpt":0.2883012953332176,"score_spread":0.2458286538302347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}