{"id":"W2753860164","doi":"10.1053/j.gastro.2017.08.049","title":"Is a Biosimilar Interchangeable With an Originator?","year":2017,"lang":"en","type":"letter","venue":"Gastroenterology","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Biosimilar; Infliximab; Medicine; Drug; Pharmacology; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0003325326,0.0006609927,0.001068983,0.0002622118,0.0002880298,0.00007592138,0.001287547,0.002282085,0.003009921],"category_scores_gemma":[0.00003248873,0.0004764632,0.0002388335,0.00005163585,0.001191542,0.0001346775,0.0002672639,0.003037948,0.0003969937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000684027,"about_ca_system_score_gemma":0.00006597458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008204851,"about_ca_topic_score_gemma":0.00008274202,"domain_scores_codex":[0.996461,0.0006455611,0.0003836835,0.001102888,0.00007996093,0.001326928],"domain_scores_gemma":[0.9977582,0.00007092574,0.0004076327,0.001557663,0.0001423031,0.00006334044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006657745,0.00008479243,0.00329904,0.00006016202,0.0007374983,0.000549347,0.0000564079,2.693267e-8,0.0005384372,0.00001150918,0.9933221,0.0006748842],"study_design_scores_gemma":[0.001355912,0.004359882,0.0004418229,0.00009048688,0.0003620966,0.00106111,0.00001519165,0.000003166095,0.001536314,0.0001820825,0.9902545,0.0003374414],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.008735473,0.0006831101,0.0007400169,0.9836081,0.002736965,0.0005385642,0.0007599681,0.0002025657,0.001995269],"genre_scores_gemma":[0.005082659,0.00007804034,0.002300682,0.9731191,0.001268143,0.00008019414,0.0005910297,0.0001170893,0.01736301],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01536774,"threshold_uncertainty_score":0.9997687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04234443204730074,"score_gpt":0.3021830642448533,"score_spread":0.2598386321975525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}