{"id":"W2753890414","doi":"10.1158/1078-0432.ccr-16-3065","title":"Immuno-oncology Trial Endpoints: Capturing Clinically Meaningful Activity","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":181,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Clinical trial; Medicine; Surrogate endpoint; Oncology; Clinical endpoint; Milestone; Clinical study design; Drug development; Cancer; Internal medicine; Phases of clinical research; Biomarker; Pharmacology; Drug","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.214657,0.001949329,0.003077082,0.003008729,0.0005908596,0.005545587,0.001335311,0.001842161,0.002649832],"category_scores_gemma":[0.2368395,0.0003528497,0.003073279,0.003847331,0.002226979,0.004463472,0.003236315,0.004158749,0.0009082659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001507874,"about_ca_system_score_gemma":0.00279353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001802226,"about_ca_topic_score_gemma":0.0003034761,"domain_scores_codex":[0.7200614,0.2469432,0.01853966,0.003559086,0.009936955,0.0009597266],"domain_scores_gemma":[0.7525296,0.1727142,0.04396385,0.01873954,0.00903304,0.003019836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.03908412,0.001698794,0.123466,0.0189015,0.009671037,0.0002091839,0.001414821,0.02413793,0.005754757,0.05772683,0.01965558,0.6982795],"study_design_scores_gemma":[0.0144731,0.08165504,0.2400755,0.01124786,0.01387122,0.002203056,0.00159214,0.09352826,0.02861422,0.3012025,0.2106745,0.0008627377],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2947968,0.1358628,0.4227949,0.02412155,0.005307313,0.03178465,0.01817431,0.001426841,0.06573083],"genre_scores_gemma":[0.8179014,0.008193358,0.1342074,0.0049177,0.001689775,0.02524338,0.005316179,0.0002911155,0.002239599],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.214657,"threshold_uncertainty_score":0.9684677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.511372098794355,"score_gpt":0.6422053277657701,"score_spread":0.1308332289714151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}