{"id":"W2753890414","doi":"10.1158/1078-0432.ccr-16-3065","title":"Immuno-oncology Trial Endpoints: Capturing Clinically Meaningful Activity","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":181,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute","keywords":"Clinical trial; Medicine; Surrogate endpoint; Oncology; Clinical endpoint; Milestone; Clinical study design; Drug development; Cancer; Internal medicine; Phases of clinical research; Biomarker; Pharmacology; Drug","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","sts","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0250286,0.0002862738,0.001339476,0.0002575161,0.001094145,0.0003064385,0.001621622,0.0008004617,0.01360679],"category_scores_gemma":[0.02363364,0.0002415108,0.0007229679,0.0002425419,0.002868601,0.0002665557,0.001521054,0.00515804,0.0005524459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009400632,"about_ca_system_score_gemma":0.003660244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002470363,"about_ca_topic_score_gemma":0.000727298,"domain_scores_codex":[0.9919903,0.001698095,0.001416812,0.001247403,0.002140838,0.001506548],"domain_scores_gemma":[0.9883782,0.005870174,0.0004473763,0.003111815,0.001189172,0.001003225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.3001928,0.001913119,0.0232401,0.0001216129,0.0004962969,0.0005607852,0.0002267145,6.922033e-7,0.03344724,0.00009192,0.009246812,0.6304619],"study_design_scores_gemma":[0.221795,0.02015892,0.1538255,0.0006340812,0.0001687632,0.00005544645,0.0003503785,0.0002479139,0.01217031,0.001411453,0.5884309,0.0007512478],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9030439,0.0003373207,0.00001599111,0.01355479,0.002110073,0.002142939,0.00001747318,0.00008835318,0.07868911],"genre_scores_gemma":[0.9633348,0.00400308,0.000209073,0.0004073657,0.006339482,0.0004556961,0.000006319603,0.00009796595,0.0251462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6297107,"threshold_uncertainty_score":0.999845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.511372098794355,"score_gpt":0.6422053277657701,"score_spread":0.1308332289714151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}