{"id":"W2753937826","doi":"10.1002/stem.2707","title":"Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development","year":2017,"lang":"en","type":"article","venue":"Stem Cells","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences; Directorate for Biological Sciences; Northwest Kidney Centers; Natural Sciences and Engineering Research Council of Canada; Eunice Kennedy Shriver National Institute of Child Health and Human Development; American Society of Nephrology","keywords":"Podocyte; Podocalyxin; Biology; Cell biology; Induced pluripotent stem cell; Nephron; Nephrin; Organoid; Kidney; Endocrinology; Embryonic stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002535003,0.0001942319,0.0002514043,0.0002462657,0.0001515155,0.0004535081,0.0002287905,0.0003297712,0.001999544],"category_scores_gemma":[0.0001377288,0.0001628803,0.0002640225,0.0001654225,0.0003127166,0.000199859,0.0002942353,0.0007720154,0.0004757103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000300813,"about_ca_system_score_gemma":0.0002071251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006796925,"about_ca_topic_score_gemma":0.0007682732,"domain_scores_codex":[0.999801,0.00002667105,0.00002483291,0.00006172907,0.00006645035,0.00001938753],"domain_scores_gemma":[0.9998412,0.00003695283,0.00004145196,0.00003889178,0.00001560242,0.00002584212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005332646,0.000009091424,0.0001060482,0.0000241373,0.000005295971,0.00005603727,0.00002466097,0.00015551,0.9984297,0.0003250061,0.00005377213,0.0007574666],"study_design_scores_gemma":[0.000009121097,0.0000440849,0.00120258,0.000005595414,0.00001156039,0.000178947,0.00002593383,0.001480731,0.9930121,0.0001288225,0.003895422,0.000005039344],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9394276,0.001979399,0.04992601,0.0003365997,0.0001581491,0.00008897144,0.003435591,0.001005789,0.003641925],"genre_scores_gemma":[0.9827029,0.0005835993,0.01122543,0.00006633819,0.000004273039,0.00005466237,0.001016521,0.0001126032,0.004233712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001999544,"threshold_uncertainty_score":0.006689191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009030090532500824,"score_gpt":0.2346525613264244,"score_spread":0.2256224707939236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}