{"id":"W2753937826","doi":"10.1002/stem.2707","title":"Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development","year":2017,"lang":"en","type":"article","venue":"Stem Cells","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute of General Medical Sciences; Directorate for Biological Sciences; Northwest Kidney Centers; Natural Sciences and Engineering Research Council of Canada; Eunice Kennedy Shriver National Institute of Child Health and Human Development; American Society of Nephrology","keywords":"Podocyte; Podocalyxin; Biology; Cell biology; Induced pluripotent stem cell; Nephron; Nephrin; Organoid; Kidney; Endocrinology; Embryonic stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009788339,0.000111464,0.0001256622,0.0000324258,0.0001130875,0.00001570618,0.0002630633,0.0001118531,0.00001639285],"category_scores_gemma":[0.000006355995,0.00009560671,0.00005082086,0.00002769586,0.00005444602,0.000002890232,0.0001186303,0.00006176692,0.00001131223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002360499,"about_ca_system_score_gemma":0.0001844053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002802622,"about_ca_topic_score_gemma":0.000009952988,"domain_scores_codex":[0.9992546,0.00002372266,0.0002049069,0.0002317609,0.000111853,0.0001731497],"domain_scores_gemma":[0.9992921,0.000001285786,0.0001350863,0.0003722782,0.00003928097,0.0001599702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006035294,0.00003114286,0.0008052849,0.0000492081,0.00003611412,0.00001233574,0.00003990148,0.00002257688,0.997277,0.00003661337,0.00101046,0.0006190336],"study_design_scores_gemma":[0.0005300967,0.00006192807,0.002492566,0.00006179891,0.00001155785,6.539273e-7,0.00001268345,0.000004170126,0.992035,0.00008643648,0.004569005,0.0001340438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980517,0.000157574,0.0001543612,0.00007991178,0.0003505195,0.0001353549,0.00002369971,0.000005049993,0.001041815],"genre_scores_gemma":[0.994272,0.00007252867,0.000275977,0.0001006218,0.00007544807,0.000008299107,0.00005269302,0.000014816,0.005127631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005241917,"threshold_uncertainty_score":0.3898728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009030090532500824,"score_gpt":0.2346525613264244,"score_spread":0.2256224707939236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}