{"id":"W2753964781","doi":"10.1002/pmic.201700116","title":"Proteomic Response of Human Umbilical Vein Endothelial Cells to Histamine Stimulation","year":2017,"lang":"en","type":"article","venue":"PROTEOMICS","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Deutsche Forschungsgemeinschaft; Ontario Ministry of Health and Long-Term Care","keywords":"Histamine; G protein-coupled receptor; Receptor; Cell biology; Signal transduction; Tumor necrosis factor alpha; Cytokine; Histamine H4 receptor; Umbilical vein; Histamine receptor; Proteomics; Chemistry; Secretion; Pharmacology; Biology; Immunology; Histamine H2 receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000143958,0.0001873196,0.0002222449,0.0002218561,0.0001483192,0.0002878384,0.0001580543,0.0002163028,0.0008438001],"category_scores_gemma":[0.0001270061,0.00009182763,0.0001981903,0.0004535597,0.00009353195,0.0001174775,0.0001116148,0.0003254027,0.0004158923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001885569,"about_ca_system_score_gemma":0.0001451753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001716955,"about_ca_topic_score_gemma":0.00149614,"domain_scores_codex":[0.9998472,0.00001703695,0.000009719323,0.00004066069,0.00004766081,0.00003760018],"domain_scores_gemma":[0.9999491,0.000009114607,0.000008245253,0.000004782209,0.0000192579,0.000009516637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001210531,0.00002438451,0.0005483,0.00003524783,0.00000977437,0.00006420273,0.00003216613,0.00002979168,0.997526,0.00003246024,0.0001089466,0.001467661],"study_design_scores_gemma":[0.00002229748,0.0002866065,0.086266,0.00001481852,0.00006169298,0.0005372217,0.0002069094,0.002341981,0.9041539,0.00008091151,0.006010772,0.00001695255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792224,0.004795134,0.007165308,0.0002412731,0.0001704057,0.000059466,0.004232992,0.00008241428,0.004030699],"genre_scores_gemma":[0.9749994,0.003469131,0.008098606,0.0004080747,0.00006470277,0.0001183784,0.006977118,0.0000273448,0.005837225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001716955,"threshold_uncertainty_score":0.003413975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01818618711423431,"score_gpt":0.2707714539010245,"score_spread":0.2525852667867902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}