{"id":"W2753964781","doi":"10.1002/pmic.201700116","title":"Proteomic Response of Human Umbilical Vein Endothelial Cells to Histamine Stimulation","year":2017,"lang":"en","type":"article","venue":"PROTEOMICS","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Deutsche Forschungsgemeinschaft; Ontario Ministry of Health and Long-Term Care","keywords":"Histamine; G protein-coupled receptor; Receptor; Cell biology; Signal transduction; Tumor necrosis factor alpha; Cytokine; Histamine H4 receptor; Umbilical vein; Histamine receptor; Proteomics; Chemistry; Secretion; Pharmacology; Biology; Immunology; Histamine H2 receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005297833,0.0001662304,0.0003165712,0.0001046394,0.0004040295,0.00003235339,0.0004413412,0.00020391,0.0004576111],"category_scores_gemma":[0.0002631547,0.0001616316,0.0000841459,0.00003305713,0.000254373,0.00007302364,0.0001846881,0.0002014458,0.0003099597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007003841,"about_ca_system_score_gemma":0.00006846802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000341076,"about_ca_topic_score_gemma":0.00003669163,"domain_scores_codex":[0.998838,0.0001415477,0.000377465,0.0003119807,0.00004785587,0.0002831476],"domain_scores_gemma":[0.9987705,0.00004773539,0.000293768,0.0007516877,0.00009580347,0.00004045687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002237999,0.0001532905,0.001015724,0.00003473446,0.00002360775,0.000002817894,0.000284858,0.00002368396,0.9946795,0.0004208748,0.000443212,0.0006796637],"study_design_scores_gemma":[0.001697042,0.0006725985,0.02046856,0.00003093349,0.00001668795,0.000005288079,0.000009509773,0.0000183743,0.9683871,0.0001741623,0.008342277,0.0001774237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962778,0.00002343273,0.0009650874,0.0002804048,0.000331668,0.001230299,0.0001198991,0.00003491973,0.0007364816],"genre_scores_gemma":[0.9858888,0.000002782587,0.002287518,0.00003746318,0.00005984347,0.00008442265,0.00002912995,0.00002457523,0.01158546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02629239,"threshold_uncertainty_score":0.6591145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01818618711423431,"score_gpt":0.2707714539010245,"score_spread":0.2525852667867902,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}