{"id":"W2753999467","doi":"10.1007/s10815-017-1028-x","title":"Two-cell embryos are more sensitive than blastocysts to AMPK-dependent suppression of anabolism and stemness by commonly used fertility drugs, a diet supplement, and stress","year":2017,"lang":"en","type":"article","venue":"Journal of Assisted Reproduction and Genetics","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Windsor","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; Wayne State University","keywords":"Anabolism; Embryo; Fertility; AMPK; Andrology; Reproductive medicine; Biology; Cell biology; Medicine; Endocrinology; Pregnancy; Genetics; Protein kinase A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003536193,0.0003840097,0.0005393843,0.0004975831,0.0002786421,0.0006758458,0.0003121694,0.0005620166,0.004598999],"category_scores_gemma":[0.0002571226,0.0002966311,0.0004093268,0.0001676612,0.0003110808,0.0004163784,0.0003482147,0.001339129,0.000920354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002592724,"about_ca_system_score_gemma":0.0003075982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006723147,"about_ca_topic_score_gemma":0.001133234,"domain_scores_codex":[0.9997525,0.00003725388,0.00004286382,0.00005908954,0.00006287812,0.00004536947],"domain_scores_gemma":[0.9995596,0.0001154092,0.0000959297,0.00005863478,0.00004081824,0.0001296157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001557591,0.00003208608,0.0001493207,0.00002032397,0.00000511193,0.00006154129,0.00001589429,0.00001245749,0.9987512,0.00007017005,0.00003984922,0.0006863143],"study_design_scores_gemma":[0.00002855193,0.0003015217,0.008296528,0.000009221146,0.00002316282,0.000315962,0.00005206553,0.0001830532,0.9875358,0.00005058424,0.003195773,0.000007802285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872767,0.002021995,0.004643361,0.0002824461,0.0001809445,0.0001170904,0.001315774,0.0001823098,0.003979415],"genre_scores_gemma":[0.9685079,0.001261409,0.004810225,0.000330251,0.00003612363,0.0001350456,0.003261353,0.0001371814,0.02152047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004598999,"threshold_uncertainty_score":0.01538521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01266470477499448,"score_gpt":0.2830776410012336,"score_spread":0.2704129362262391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}