{"id":"W2754084527","doi":"10.3389/fonc.2017.00220","title":"Preclinical Modeling and Therapeutic Avenues for Cancer Metastasis to the Central Nervous System","year":2017,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Metastasis; Cancer; Leptomeninges; Primary tumor; Disease; Brain metastasis; Central nervous system; In vivo; Oncology; Pathology; Bioinformatics; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005794201,0.0008189193,0.0009447054,0.001774701,0.0002778815,0.000884536,0.0008845414,0.001033402,0.003508351],"category_scores_gemma":[0.0005992568,0.000295617,0.0006383912,0.001011636,0.0005018622,0.001055614,0.0005650392,0.001919053,0.001800867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000700399,"about_ca_system_score_gemma":0.0009220791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009656445,"about_ca_topic_score_gemma":0.001382481,"domain_scores_codex":[0.9998413,0.00003521259,0.00001675108,0.00002457105,0.00006320899,0.00001884336],"domain_scores_gemma":[0.9997901,0.00009167555,0.00003040557,0.000009898297,0.00005858267,0.0000193271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001347994,0.0002755156,0.000294538,0.03110669,0.0001300561,0.0005884683,0.0001433786,0.002245863,0.02298533,0.02177065,0.03504627,0.8852784],"study_design_scores_gemma":[0.0000230257,0.0001976576,0.0004829606,0.002533385,0.0001109571,0.001308188,0.00004277705,0.000343366,0.004509605,0.003399795,0.987022,0.00002630551],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005508824,0.9941921,0.001047714,0.0004027963,0.0002677001,0.00002894969,0.00006838959,0.00002423538,0.003417346],"genre_scores_gemma":[0.00298925,0.9949048,0.0007165343,0.0001896876,0.00009148854,0.00002522306,0.00008075314,0.000004152249,0.0009982185],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003508351,"threshold_uncertainty_score":0.01173663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2410015553159017,"score_gpt":0.4825367202974138,"score_spread":0.2415351649815121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}