{"id":"W2754084527","doi":"10.3389/fonc.2017.00220","title":"Preclinical Modeling and Therapeutic Avenues for Cancer Metastasis to the Central Nervous System","year":2017,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Metastasis; Cancer; Leptomeninges; Primary tumor; Disease; Brain metastasis; Central nervous system; In vivo; Oncology; Pathology; Bioinformatics; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007899893,0.0003082042,0.002387089,0.0001266436,0.000143211,0.00002680632,0.0002389052,0.0003261942,0.000004777363],"category_scores_gemma":[0.0001301334,0.0001780369,0.0004178386,0.000065303,0.00008196342,0.00001554914,0.00007816138,0.0003291785,0.000002999549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007385341,"about_ca_system_score_gemma":0.0006247812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000150099,"about_ca_topic_score_gemma":0.0001697515,"domain_scores_codex":[0.998027,0.000365526,0.000574225,0.0004735049,0.0001163906,0.0004433296],"domain_scores_gemma":[0.9987367,0.0002691636,0.0002770629,0.0005149874,0.0000426052,0.0001595254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001191023,0.00007185968,0.0000803599,0.00455363,0.001079406,0.00005019562,0.0001391032,0.00004604809,6.041946e-9,0.00006385205,0.002920365,0.9908761],"study_design_scores_gemma":[0.0008498287,0.0004995601,0.00002749762,0.003747207,0.005254091,0.0000925163,0.0001440669,0.002113302,4.547536e-8,0.00004176585,0.9870837,0.0001463932],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001822066,0.9871661,0.005304342,0.001298589,0.002590948,0.003259517,0.000260605,0.00001788063,0.00008381982],"genre_scores_gemma":[0.0002394777,0.9871756,0.009532333,0.0002786825,0.0006230745,0.001826194,0.00005388819,0.00005134747,0.0002193687],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9907297,"threshold_uncertainty_score":0.7260133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2410015553159017,"score_gpt":0.4825367202974138,"score_spread":0.2415351649815121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}