{"id":"W2754128084","doi":"10.1038/onc.2017.318","title":"Loss of PRP4K drives anoikis resistance in part by dysregulation of epidermal growth factor receptor endosomal trafficking","year":2017,"lang":"en","type":"article","venue":"Oncogene","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Beatrice Hunter Cancer Research Institute; Université de Montréal; Centre Hospitalier de l’Université de Montréal; Izaak Walton Killam Health Centre; Dalhousie University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Killam Trusts; Cure Brain Cancer Foundation; Terry Fox Foundation; QEII Foundation; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Anoikis; Biology; Cell biology; Cancer research; Epidermal growth factor receptor; Epidermal growth factor; Cancer cell; Cancer; Cell culture","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001045064,0.0001052318,0.0001829562,0.00002800905,0.00005480301,0.000007862401,0.0001642752,0.0001292846,0.00003255171],"category_scores_gemma":[0.00004384457,0.0001092916,0.00008280847,0.00003022393,0.0001201408,0.000009681938,0.00002182858,0.00004173847,7.448377e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001002225,"about_ca_system_score_gemma":0.00003694936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002990644,"about_ca_topic_score_gemma":0.0002947017,"domain_scores_codex":[0.9991934,0.00003420709,0.0002882827,0.0002199236,0.0001208727,0.0001433018],"domain_scores_gemma":[0.9993384,0.000007260246,0.0002614982,0.0002916867,0.00006479957,0.00003631913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001443823,0.00006098509,0.07095169,0.00004753652,0.0000188167,0.000001760636,0.0001107447,0.000005930118,0.927863,0.00007002664,0.00005766236,0.0006674724],"study_design_scores_gemma":[0.0006207422,0.00007619424,0.05555781,0.00004715149,0.000009567222,6.439142e-7,0.00001630448,0.00001487518,0.9356853,0.00002054557,0.007838712,0.0001121332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971538,0.0007887948,0.001213971,0.00008490896,0.00009719939,0.000115583,0.0001047077,0.000003596555,0.0004374624],"genre_scores_gemma":[0.9978187,0.0002793784,0.0005041416,0.000007282574,0.0000923915,0.000005430959,0.000977437,0.00001320573,0.0003020201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01539388,"threshold_uncertainty_score":0.4456782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01137431571700448,"score_gpt":0.2372024615065112,"score_spread":0.2258281457895067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}