{"id":"W2754190914","doi":"10.1136/annrheumdis-2017-eular.3348","title":"OP0203 Impact of adalimumab serum concentration on efficacy and association between ANTI-DRUG antibodies and serum concentration: 24 week results from a phase III study comparing SB5 (an adalimumab biosimilar) with reference adalimumab in patients with rheumatoid arthritis","year":2017,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital","funders":"Pfizer; Amgen","keywords":"Adalimumab; Medicine; Biosimilar; Rheumatoid arthritis; Trough level; Internal medicine; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004614245,0.0003587646,0.001032588,0.00006173756,0.0004265524,0.0001281555,0.0003650379,0.0001436867,0.00002761508],"category_scores_gemma":[0.0004939897,0.0002246541,0.00008319915,0.0001200282,0.0005252493,0.0004336984,0.0001394882,0.0002404533,8.85668e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004116356,"about_ca_system_score_gemma":0.0001238175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001073296,"about_ca_topic_score_gemma":0.0003031684,"domain_scores_codex":[0.9973238,0.0006771975,0.0008522482,0.0004997186,0.0002566658,0.0003904439],"domain_scores_gemma":[0.9969307,0.0006464067,0.001369397,0.0006918613,0.0002638436,0.00009774693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004609791,0.002499244,0.981871,0.00004961022,0.001195048,0.00000179624,0.001426308,0.00003032383,0.0001257721,0.00003261805,0.0001489268,0.008009566],"study_design_scores_gemma":[0.02852061,0.002844274,0.962939,0.001753131,0.0002305109,7.810677e-7,0.0006963313,0.0001069681,0.002533008,0.00009297649,0.00000602824,0.0002763424],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948437,0.0009641272,0.000004210289,0.0004686375,0.00007607378,0.0009692478,0.002607477,0.00002226706,0.00004420977],"genre_scores_gemma":[0.9988323,0.0008279404,0.00004541632,0.00004243034,0.000008233798,0.000008577148,0.0002041959,0.00001807506,0.00001279763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02391082,"threshold_uncertainty_score":0.9161129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05134418831104503,"score_gpt":0.332393368620422,"score_spread":0.281049180309377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}