{"id":"W2754190914","doi":"10.1136/annrheumdis-2017-eular.3348","title":"OP0203 Impact of adalimumab serum concentration on efficacy and association between ANTI-DRUG antibodies and serum concentration: 24 week results from a phase III study comparing SB5 (an adalimumab biosimilar) with reference adalimumab in patients with rheumatoid arthritis","year":2017,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital","funders":"Pfizer; Amgen","keywords":"Adalimumab; Medicine; Biosimilar; Rheumatoid arthritis; Trough level; Internal medicine; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003835507,0.0008011356,0.001291464,0.0003307737,0.000281753,0.00104711,0.0006555176,0.00107962,0.001708298],"category_scores_gemma":[0.00349828,0.0004349924,0.001942399,0.0004509038,0.0006813922,0.0006527273,0.000328598,0.001849386,0.0004300013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007018837,"about_ca_system_score_gemma":0.0008651122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001428268,"about_ca_topic_score_gemma":0.001292827,"domain_scores_codex":[0.9982284,0.0009510297,0.0001136942,0.000268881,0.0002783319,0.0001598127],"domain_scores_gemma":[0.997229,0.001173573,0.0006656741,0.0002265324,0.0002352518,0.0004698921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8511167,0.01330855,0.03459921,0.0003121656,0.002437244,0.0001856263,0.0001743771,0.001319944,0.04052176,0.00009169368,0.000715808,0.05521697],"study_design_scores_gemma":[0.1212664,0.6231234,0.2294359,0.00003794794,0.003357446,0.0004590511,0.0001050956,0.004158374,0.01632546,0.0001587919,0.001488944,0.00008330537],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980187,0.0007102955,0.0003075985,0.00006603909,0.00002967075,0.0001172263,0.0003092483,0.00002746497,0.0004138361],"genre_scores_gemma":[0.9984915,0.0001215991,0.0003631348,0.0001062221,0.0000394359,0.00006380716,0.0004036831,0.000009455594,0.0004013059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003835507,"threshold_uncertainty_score":0.02028435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05134418831104503,"score_gpt":0.332393368620422,"score_spread":0.281049180309377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}