{"id":"W2754234593","doi":"10.1182/blood.v128.22.2843.2843","title":"Minimal Residual Disease (MRD) Assessment By Multiparametric Flow Cytometry Is Prognostic for Progression-Free Survival in Phase 1/1b Relapsed/Refractory Acute Myeloid Leukemia (AML) Patients Treated with Idasanutlin MDM2 Antagonist","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Minimal residual disease; Oncology; Cytarabine; Internal medicine; Flow cytometry; Refractory (planetary science); Myeloid leukemia; Leukemia; Clinical trial; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005881338,0.000214666,0.0004399733,0.0003687269,0.0001468663,0.0003905893,0.0002567233,0.0002583247,0.001220852],"category_scores_gemma":[0.0005826976,0.0001228314,0.0001993961,0.0002068088,0.0001701954,0.000192889,0.0001686774,0.0004484087,0.0002631871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002835788,"about_ca_system_score_gemma":0.0001871066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002000503,"about_ca_topic_score_gemma":0.0004255417,"domain_scores_codex":[0.9998287,0.000051823,0.00002041622,0.00004491199,0.00003142715,0.00002273476],"domain_scores_gemma":[0.9996312,0.00008716026,0.0001211596,0.00002037186,0.00003148552,0.0001086222],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.05923067,0.001623245,0.6959203,0.000445761,0.0002652321,0.0003783467,0.0002141395,0.001187717,0.1396542,0.0001730173,0.002566217,0.0983411],"study_design_scores_gemma":[0.001683707,0.01829553,0.9473668,0.00006187751,0.0003050092,0.001783109,0.0001119477,0.00255645,0.02342749,0.0002469409,0.004128306,0.00003283098],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962106,0.001904557,0.0003433363,0.0001033747,0.00001750088,0.0001010115,0.0005874506,0.00002106833,0.0007111238],"genre_scores_gemma":[0.9973965,0.0003392896,0.0006155276,0.00008325757,0.00001855831,0.0001036207,0.0009939006,0.000002940928,0.000446469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001220852,"threshold_uncertainty_score":0.00408417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570595113027315,"score_gpt":0.3182589468307045,"score_spread":0.3025529957004313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}