{"id":"W2754237340","doi":"10.1038/s41598-017-12052-9","title":"GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Basic Energy Sciences; National Institute of General Medical Sciences; National Institutes of Health; National Cancer Institute; Office of Science; Bristol-Myers Squibb; U.S. Department of Energy","keywords":"Darunavir; Amprenavir; Moiety; Chemistry; Lopinavir; Raltegravir; HIV-1 protease; Stereochemistry; Protease; Isostere; Atazanavir; Human immunodeficiency virus (HIV); Virology; Biology; Biochemistry; Enzyme; Viral load; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009056857,0.0002217599,0.0001514743,0.00009449,0.00008579833,0.0001557934,0.0002452308,0.0001929172,0.000668243],"category_scores_gemma":[0.00009485319,0.00009357575,0.0001564835,0.00006493255,0.000146957,0.0001447777,0.0001083677,0.0003265684,0.0004322483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001729828,"about_ca_system_score_gemma":0.0001203855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004855828,"about_ca_topic_score_gemma":0.0007552617,"domain_scores_codex":[0.9999145,0.00001424431,0.000006457345,0.00001765007,0.00002929376,0.00001786254],"domain_scores_gemma":[0.9999512,0.000007340198,0.00001859962,0.000006984775,0.000004904477,0.00001095789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004371831,0.00001307543,0.0001036027,0.00001746763,0.000003557449,0.00002624909,0.000004174199,0.0001313078,0.9972734,0.0000362574,0.00003896535,0.002308231],"study_design_scores_gemma":[0.00002453988,0.0007064294,0.001652754,0.000002764137,0.00001169687,0.000426129,0.0000044874,0.0007951395,0.9934683,0.00001208441,0.002889463,0.000006261313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918017,0.002411345,0.003131279,0.00005500557,0.00002055042,0.00003922282,0.0003424202,0.0001405891,0.002058004],"genre_scores_gemma":[0.9945538,0.0005335073,0.003111955,0.00003464836,0.000006783253,0.00001415209,0.0004518862,0.0000137146,0.001279592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000668243,"threshold_uncertainty_score":0.002235532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01599578536965825,"score_gpt":0.2607146948092411,"score_spread":0.2447189094395829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}