{"id":"W2754309875","doi":"10.7150/thno.21630","title":"Acute Inflammatory Response Following Increased Blood-Brain Barrier Permeability Induced by Focused Ultrasound is Dependent on Microbubble Dose","year":2017,"lang":"en","type":"article","venue":"Theranostics","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":264,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Microbubbles; Neuroinflammation; Medicine; Blood–brain barrier; Inflammation; Edema; Vascular permeability; In vivo; Ultrasound; Pathology; Pharmacology; Internal medicine; Central nervous system; Biology; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007893502,0.0005361655,0.0003607463,0.0002767404,0.0001852176,0.0003672393,0.000239111,0.0004233971,0.001798618],"category_scores_gemma":[0.0008153131,0.0001847846,0.0002667051,0.0002081197,0.0007109295,0.000434067,0.0002582385,0.0007806951,0.0003198241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000370304,"about_ca_system_score_gemma":0.0003253443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003008179,"about_ca_topic_score_gemma":0.0003834862,"domain_scores_codex":[0.9995679,0.0001431962,0.000041828,0.00006092244,0.0001071802,0.0000789754],"domain_scores_gemma":[0.9993017,0.0002315206,0.000302058,0.00003924963,0.00006563418,0.00005981465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008244326,0.0001504572,0.0006506783,0.0002130956,0.000009869956,0.0001324791,0.00004897293,0.00008736249,0.9946596,0.0001025571,0.0000537908,0.003066712],"study_design_scores_gemma":[0.00004509735,0.004341364,0.0143731,0.00003958323,0.00006464771,0.0005870128,0.00006168082,0.0008258041,0.9784015,0.000147495,0.001098612,0.00001412621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810084,0.006684685,0.01008502,0.0003374116,0.00006764623,0.0002714231,0.0001957995,0.00009298581,0.001256668],"genre_scores_gemma":[0.9916024,0.002626705,0.004387723,0.0002054389,0.00005644598,0.0002644207,0.0001182429,0.00001271354,0.0007259461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001798618,"threshold_uncertainty_score":0.006017029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01055050139630244,"score_gpt":0.2370951340673817,"score_spread":0.2265446326710792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}