{"id":"W2754310746","doi":"10.1124/pr.115.012062","title":"Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications","year":2017,"lang":"en","type":"review","venue":"Pharmacological Reviews","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":247,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Western University","funders":"National Eye Institute; National Science Foundation; Canadian Institutes of Health Research; Vlaamse regering; Hungarian Scientific Research Fund; European Foundation for the Study of Diabetes; National Research, Development and Innovation Office; Universiteit Gent; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Institutes of Health; National Institute of General Medical Sciences; European Association for the Study of Diabetes","keywords":"Gap junction; Connexin; Connexon; Cell biology; Pannexin; Neuroscience; Biology; Myocyte; Cell type; Intracellular; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001472538,0.0006549406,0.002948662,0.0001028803,0.0002696085,0.00006206775,0.000552487,0.0003973344,0.00006028598],"category_scores_gemma":[0.0009027548,0.0004555633,0.001056385,0.0001195899,0.0004050976,0.000007418979,0.0007075793,0.0005877163,0.00002159761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004603178,"about_ca_system_score_gemma":0.0003695656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001140641,"about_ca_topic_score_gemma":0.000006102675,"domain_scores_codex":[0.9952317,0.001685915,0.0009582601,0.001412963,0.000111761,0.0005994317],"domain_scores_gemma":[0.9977559,0.0001032531,0.0004654163,0.0007450098,0.00003783206,0.000892583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000216933,0.0001060731,0.00007426906,0.002690668,0.0003236299,0.00003262133,0.000004869209,2.767491e-7,0.0000464863,0.00009569384,0.002416258,0.9941875],"study_design_scores_gemma":[0.0005539907,0.0002195852,0.00024145,0.0006585636,0.001020767,0.00009388009,0.000001872258,0.00000328277,8.85911e-7,0.0000465312,0.9966907,0.0004685034],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002104272,0.9958343,0.0000497517,0.0005473536,0.0001772981,0.002921802,0.00009929488,0.00002023593,0.0001395501],"genre_scores_gemma":[0.0003679782,0.9955711,0.00009099416,0.001934012,0.0003977967,0.001166576,0.0003290236,0.00003889277,0.0001035806],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9942744,"threshold_uncertainty_score":0.9997896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1962248859841216,"score_gpt":0.450040531696715,"score_spread":0.2538156457125935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}