{"id":"W2754363049","doi":"","title":"Designing Randomized Clinical Trials for Rare Diseases","year":2011,"lang":"en","type":"dissertation","venue":"TSpace","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Arthritis Network; Hospital for Sick Children; Natural Sciences and Engineering Research Council of Canada; Amgen","keywords":"Randomized controlled trial; Medicine; Medical physics; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.4235643,0.002871838,0.008577798,0.005618779,0.001112402,0.005578455,0.003529178,0.008319554,0.005710552],"category_scores_gemma":[0.6449931,0.00224519,0.005982425,0.003085522,0.005609507,0.004946885,0.003550953,0.004688057,0.0009686886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004421561,"about_ca_system_score_gemma":0.01229882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000616067,"about_ca_topic_score_gemma":0.0005785476,"domain_scores_codex":[0.2838755,0.6691301,0.02533301,0.009931783,0.01040221,0.001327301],"domain_scores_gemma":[0.24427,0.6770704,0.04618913,0.01930399,0.01109771,0.002068838],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.05361304,0.003494686,0.02402302,0.1153378,0.05183262,0.0008836499,0.002898402,0.1331003,0.003075958,0.1652295,0.01495383,0.4315572],"study_design_scores_gemma":[0.1485415,0.04133012,0.007081591,0.05412033,0.02869404,0.0006577894,0.001521372,0.1928177,0.008096131,0.4570937,0.05919504,0.0008507209],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.03690923,0.02839911,0.7269909,0.01153842,0.008482443,0.1786536,0.001505471,0.001273397,0.006247464],"genre_scores_gemma":[0.1267041,0.00466605,0.7051065,0.00435975,0.0009842871,0.1571846,0.0004027059,0.00009935063,0.0004927299],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.5764357,"threshold_uncertainty_score":0.7108479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.7329984761159076,"score_gpt":0.5965884474134409,"score_spread":0.1364100287024668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}