{"id":"W2754367908","doi":"10.1002/chem.201704277","title":"Total Synthesis of Skyllamycins A–C","year":2017,"lang":"en","type":"article","venue":"Chemistry - A European Journal","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Australian Research Council; Natural Sciences and Engineering Research Council of Canada","keywords":"Moiety; Depsipeptide; Natural product; Total synthesis; Chemistry; Amide; Glycine; Combinatorial chemistry; Peptide synthesis; Stereochemistry; Amino acid; Organic chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001365267,0.0006633748,0.0003804486,0.000417659,0.0002338966,0.000244081,0.000293384,0.00023034,0.002243442],"category_scores_gemma":[0.0001855149,0.000178159,0.0002799287,0.0003730541,0.0001707765,0.0003229032,0.0004473713,0.0005022079,0.001741117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003008148,"about_ca_system_score_gemma":0.0008480355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004980827,"about_ca_topic_score_gemma":0.000784593,"domain_scores_codex":[0.9998399,0.00001821229,0.00001763927,0.00003551499,0.00004961759,0.00003917879],"domain_scores_gemma":[0.9998797,0.00001227728,0.00002104975,0.00001712077,0.00003276854,0.00003694512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001049781,0.0000300093,0.00009810765,0.000246732,0.00002642471,0.0001782909,0.00004564566,0.000605861,0.9848273,0.0009115678,0.0004252216,0.01249992],"study_design_scores_gemma":[0.00004245387,0.0004983652,0.0007897195,0.00002614131,0.00003600647,0.0003902383,0.00002314406,0.0006265847,0.9728584,0.0003223266,0.02436077,0.00002595935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8375619,0.008123035,0.09040993,0.0002885519,0.0003422116,0.001026108,0.009603623,0.001519055,0.05112566],"genre_scores_gemma":[0.9308178,0.004971571,0.04869156,0.0001834468,0.00003100003,0.0004435468,0.003108644,0.0001613627,0.01159108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002243442,"threshold_uncertainty_score":0.007505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008990982515891468,"score_gpt":0.2255197008757384,"score_spread":0.2165287183598469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}