{"id":"W2754409727","doi":"10.1016/j.preteyeres.2017.09.001","title":"Complement factor H in AMD: Bridging genetic associations and pathobiology","year":2017,"lang":"en","type":"review","venue":"Progress in Retinal and Eye Research","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Eye Institute; Centre for Blood Research, University of British Columbia; Research to Prevent Blindness; National Institutes of Health; Foundation Fighting Blindness","keywords":"Factor H; Drusen; Macular degeneration; Complement system; Biology; Complement membrane attack complex; Alternative complement pathway; Complement factor B; Retinal; Immunology; Cell biology; Medicine; Antibody; Biochemistry; Ophthalmology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009435146,0.0007469975,0.001300096,0.00190512,0.0002399908,0.001145819,0.0008800409,0.001268772,0.002181908],"category_scores_gemma":[0.001107422,0.0002331988,0.0004738193,0.001805654,0.0006640013,0.001112894,0.0009342752,0.001835619,0.0007146437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000586485,"about_ca_system_score_gemma":0.001631888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002103448,"about_ca_topic_score_gemma":0.003277193,"domain_scores_codex":[0.9997559,0.00004060141,0.000042415,0.00004137118,0.00009506368,0.0000245814],"domain_scores_gemma":[0.999472,0.0002736048,0.00007592972,0.00001299044,0.0001260425,0.00003951214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000128756,0.00005564425,0.0006812896,0.01224073,0.0001847107,0.0002913574,0.0000470245,0.0002806974,0.001305695,0.004060945,0.02055113,0.9601721],"study_design_scores_gemma":[0.00006771872,0.0001265682,0.002905591,0.00729647,0.0005023368,0.002463901,0.0001420872,0.0002656931,0.0007334495,0.006380417,0.9790671,0.00004867039],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007967201,0.9992024,0.00008101075,0.0002757226,0.000100523,0.000001924973,0.000009662454,0.000002634363,0.0002464912],"genre_scores_gemma":[0.0007729033,0.9984797,0.0001418596,0.0001747778,0.0002306829,0.000002652436,0.00001842933,5.388926e-7,0.0001785588],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002181908,"threshold_uncertainty_score":0.007299244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3616582955715648,"score_gpt":0.5646848029959984,"score_spread":0.2030265074244336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}