{"id":"W2754409727","doi":"10.1016/j.preteyeres.2017.09.001","title":"Complement factor H in AMD: Bridging genetic associations and pathobiology","year":2017,"lang":"en","type":"review","venue":"Progress in Retinal and Eye Research","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Eye Institute; Centre for Blood Research, University of British Columbia; Research to Prevent Blindness; National Institutes of Health; Foundation Fighting Blindness","keywords":"Factor H; Drusen; Macular degeneration; Complement system; Biology; Complement membrane attack complex; Alternative complement pathway; Complement factor B; Retinal; Immunology; Cell biology; Medicine; Antibody; Biochemistry; Ophthalmology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006907923,0.0002458133,0.001122743,0.0004166455,0.0001941367,0.0001007639,0.0001444295,0.0001879667,0.00002846628],"category_scores_gemma":[0.0001982144,0.0001789016,0.0001091078,0.0001729259,0.0003451024,0.00002967402,0.0003112562,0.00067869,0.00001252631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002118305,"about_ca_system_score_gemma":0.0002248616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001559993,"about_ca_topic_score_gemma":0.00003952091,"domain_scores_codex":[0.9975803,0.0004747057,0.0004664554,0.0005255345,0.0003701418,0.0005828984],"domain_scores_gemma":[0.9990512,0.0002053608,0.0001609397,0.0002812337,0.00009342712,0.0002078911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00002360491,0.0001188058,0.3968805,0.004278556,0.00004171282,0.0003998797,0.00002769267,2.61157e-9,4.22455e-8,0.0000269744,0.000009430918,0.5981928],"study_design_scores_gemma":[0.0008936641,0.0004773636,0.7729618,0.01437067,0.0001559709,0.00007377297,0.00002850548,0.00002801456,1.406952e-7,0.0001166651,0.2106974,0.0001960728],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02984894,0.9680954,3.628807e-7,0.0001938577,0.00002867247,0.001430581,0.0001324391,0.000008193747,0.0002615405],"genre_scores_gemma":[0.02707779,0.9719221,0.0001583454,0.00000427234,0.00008990862,0.0003930951,0.0001708518,0.00002467348,0.0001589857],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5979968,"threshold_uncertainty_score":0.7295393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3616582955715648,"score_gpt":0.5646848029959984,"score_spread":0.2030265074244336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}