{"id":"W2754662782","doi":"10.3390/pharmaceutics9030036","title":"Augmented Renal Clearance in Critical Illness: An Important Consideration in Drug Dosing","year":2017,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Dosing; Cochrane Library; MEDLINE; Intensive care medicine; Renal function; Observational study; Critically ill; Emergency medicine; Internal medicine; Meta-analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008803732,0.0004602695,0.001562689,0.0003771037,0.0001349346,0.0001200707,0.0002357854,0.0002503555,0.00008902995],"category_scores_gemma":[0.000380298,0.0004212483,0.0002072851,0.000223311,0.0002164366,0.0001531717,0.00009660942,0.001367939,0.00003284343],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002199499,"about_ca_system_score_gemma":0.0004866212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003968305,"about_ca_topic_score_gemma":0.00005347528,"domain_scores_codex":[0.99703,0.0002312735,0.0012394,0.000582839,0.0003596713,0.0005568737],"domain_scores_gemma":[0.9985157,0.0002099533,0.0003438197,0.0005221746,0.0001026529,0.0003056696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001956908,0.0009206229,0.000340169,0.0144258,0.0001063335,0.00203392,0.0003358931,0.00001444776,0.00009317046,0.0006338601,0.0004348881,0.9804652],"study_design_scores_gemma":[0.002081299,0.00005172056,0.0001458162,0.01750161,0.001014718,0.0002373118,0.00003281118,0.007595666,0.0001885438,0.00005482966,0.9705431,0.0005525335],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009543287,0.9959208,0.00003652678,0.0004036864,0.0006765667,0.001103194,0.00003580187,0.00004692213,0.0008221975],"genre_scores_gemma":[0.03565238,0.962867,0.0003887774,0.0003258416,0.0004016356,0.00001564349,0.0001560022,0.00008848316,0.0001042701],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9799126,"threshold_uncertainty_score":0.9998239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2794798512329839,"score_gpt":0.5430575493466337,"score_spread":0.2635776981136498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}