{"id":"W2754675125","doi":"10.1021/acs.bioconjchem.7b00509","title":"Transglutaminase-Catalyzed Bioconjugation Using One-Pot Metal-Free Bioorthogonal Chemistry","year":2017,"lang":"ca","type":"article","venue":"Bioconjugate Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"PROTEO; Centre in Green Chemistry and Catalysis","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bioorthogonal chemistry; Bioconjugation; Chemistry; Combinatorial chemistry; Azide; Cycloaddition; Biochemistry; Tetrazine; Click chemistry; Substrate (aquarium); Linker; Chemical biology; Catalysis; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002933599,0.0007218297,0.0003736289,0.0002553721,0.0001795843,0.0005011599,0.0004711791,0.0004203674,0.0006802091],"category_scores_gemma":[0.0002189511,0.0002332935,0.0004238724,0.0003929776,0.0003594869,0.0004465479,0.0004895738,0.0006402417,0.0004689933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003443407,"about_ca_system_score_gemma":0.0002771586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002947201,"about_ca_topic_score_gemma":0.0005488129,"domain_scores_codex":[0.9997216,0.0000399008,0.00002643443,0.00009277444,0.00006460167,0.00005468876],"domain_scores_gemma":[0.9999081,0.00001310981,0.00003071832,0.00002575874,0.00000957143,0.00001269648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003447839,0.00002956809,0.00008055443,0.00006709938,0.00001472441,0.00007424434,0.00002360402,0.00023854,0.9934102,0.0008483839,0.00006793961,0.00511075],"study_design_scores_gemma":[0.000003849289,0.00008639621,0.0001310179,0.000001311239,0.000008887766,0.0001398515,0.00000322821,0.0004107334,0.9975671,0.00007673554,0.001565951,0.000004983094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8397561,0.002167217,0.1513818,0.0002024052,0.00009929747,0.000225623,0.000288226,0.0008558023,0.005023485],"genre_scores_gemma":[0.94557,0.001494393,0.04859621,0.00007809843,0.0000138784,0.0000930335,0.0003415897,0.00007166126,0.003741196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007218297,"threshold_uncertainty_score":0.002498329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05982161860547768,"score_gpt":0.2922959416700943,"score_spread":0.2324743230646166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}