{"id":"W2754724354","doi":"10.1021/acs.biochem.7b00655","title":"The Too Many Faces of PD-L1: A Comprehensive Conformational Analysis Study","year":2017,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Li Ka Shing Institute of Virology, University of Alberta; Kom op tegen Kanker; Alberta Cancer Foundation; Compute Canada; Kræftens Bekæmpelse","keywords":"Molecular dynamics; Chemistry; Computational biology; Binding site; Plasma protein binding; Binding pocket; Protein structure; Biophysics; Biology; Biochemistry; Computational chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001554572,0.0003139749,0.0003809649,0.0002907706,0.000402699,0.000330669,0.0003361853,0.0002622073,0.00119228],"category_scores_gemma":[0.0002157985,0.0001926705,0.0004429083,0.000362266,0.0002508001,0.0005250548,0.0002350892,0.000441501,0.0001227735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002841948,"about_ca_system_score_gemma":0.0003864543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002094749,"about_ca_topic_score_gemma":0.002203414,"domain_scores_codex":[0.9999546,0.000006873342,0.000001769334,0.00001351232,0.00001241644,0.00001090075],"domain_scores_gemma":[0.9999427,0.00001924859,0.000008660224,0.00001023879,0.000009025421,0.00001006732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.0004926632,0.0002816792,0.02104777,0.0003486489,0.0002899621,0.0006618185,0.0002502556,0.7938291,0.1185076,0.01527199,0.001828362,0.0471902],"study_design_scores_gemma":[0.00001838012,0.0001094845,0.008444174,0.00001113223,0.0000542425,0.0001152351,0.00007841087,0.9789768,0.006639985,0.004168666,0.001357842,0.00002556667],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797004,0.001089534,0.01682855,0.000155478,0.000008100707,0.00001999901,0.0002747181,0.0001180846,0.001805244],"genre_scores_gemma":[0.9921256,0.00069103,0.006306682,0.00002229205,0.000004472087,0.0000192223,0.0004775755,0.00002382732,0.0003294082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002094749,"threshold_uncertainty_score":0.004165113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02421401266249711,"score_gpt":0.3232387343301488,"score_spread":0.2990247216676516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}