{"id":"W2754732860","doi":"10.1038/s41598-017-11526-0","title":"Polycystin-1 inhibits eIF2α phosphorylation and cell apoptosis through a PKR-eIF2α pathway","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; Kidney Foundation of Canada; York University","keywords":"Protein kinase R; Phosphorylation; Cell biology; Biology; Apoptosis; EIF-2 kinase; eIF2; Kinase; Molecular biology; Signal transduction; Protein kinase A; Translation (biology); Biochemistry; Mitogen-activated protein kinase kinase; Cyclin-dependent kinase 2; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001421915,0.0004598489,0.0003387796,0.0002361203,0.0001746329,0.0002233344,0.0001887741,0.0002477393,0.0008096648],"category_scores_gemma":[0.000136626,0.00009981793,0.000332826,0.0001896865,0.0001874295,0.0001518347,0.000188072,0.0005801233,0.0002363086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002154484,"about_ca_system_score_gemma":0.0002234681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002484247,"about_ca_topic_score_gemma":0.000473097,"domain_scores_codex":[0.9998569,0.00002439901,0.00002257099,0.00002417974,0.00004162986,0.00003037757],"domain_scores_gemma":[0.9999204,0.00001150007,0.00002643709,0.000009465009,0.00001212654,0.00001998856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005138126,0.0002209804,0.0002952623,0.0001949773,0.00002469604,0.00007323045,0.00001538151,0.000137875,0.9942971,0.0000655585,0.0001319711,0.004029215],"study_design_scores_gemma":[0.0001255296,0.00131601,0.007666925,0.00001503363,0.00002980673,0.0005019775,0.00001647031,0.0009752185,0.985698,0.00004778329,0.003601156,0.000006062451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888321,0.007196245,0.001386882,0.0001406671,0.0001019489,0.00005081137,0.0002452472,0.0001220884,0.001923946],"genre_scores_gemma":[0.9919552,0.003214488,0.001790523,0.00009770978,0.00003379653,0.00006514694,0.0007877704,0.00001413287,0.002041165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008096648,"threshold_uncertainty_score":0.002708614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019500238441136,"score_gpt":0.2349256774828367,"score_spread":0.2247306750984253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}