{"id":"W2754782458","doi":"10.1111/jth.13847","title":"Phase IIa study of dabigatran etexilate in children with venous thrombosis: pharmacokinetics, safety, and tolerability","year":2017,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Boehringer Ingelheim","keywords":"Medicine; Dabigatran; Pharmacodynamics; Pharmacokinetics; Tolerability; Adverse effect; Anesthesia; Partial thromboplastin time; Direct thrombin inhibitor; Thrombin time; Pharmacology; Warfarin; Internal medicine; Atrial fibrillation; Coagulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001122513,0.00110917,0.002044202,0.0002755961,0.0003179756,0.001128952,0.0005562527,0.0009713086,0.002075969],"category_scores_gemma":[0.001522478,0.0005279414,0.001317182,0.000370049,0.0009383905,0.0008318072,0.0002384826,0.002854014,0.000619237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000845591,"about_ca_system_score_gemma":0.001638602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001565269,"about_ca_topic_score_gemma":0.002374467,"domain_scores_codex":[0.9994057,0.0003405578,0.00003830351,0.00006934137,0.00005197839,0.00009404138],"domain_scores_gemma":[0.9990987,0.0002226414,0.0002103882,0.0001063912,0.00006331546,0.0002986662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7774798,0.026924,0.0188621,0.001023813,0.00373086,0.001405002,0.0007605882,0.004546086,0.05300007,0.001105677,0.004941158,0.1062208],"study_design_scores_gemma":[0.5503831,0.3802122,0.0404858,0.0001346898,0.001548846,0.002183449,0.0002782667,0.001943207,0.01108019,0.0004516985,0.01122133,0.00007715091],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908749,0.00410527,0.001162816,0.0004552765,0.00009564475,0.0008714502,0.0009893663,0.00007940426,0.001365806],"genre_scores_gemma":[0.9899677,0.003787921,0.001419844,0.000652309,0.0001166201,0.0007858044,0.001517298,0.00004158777,0.001711002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002075969,"threshold_uncertainty_score":0.006944835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06530644640157722,"score_gpt":0.3686124081619904,"score_spread":0.3033059617604131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}