{"id":"W2754849847","doi":"10.1164/rccm.201704-0717oc","title":"Tezacaftor/Ivacaftor in Subjects with Cystic Fibrosis and <i>F508del</i> / <i>F508del-CFTR</i> or <i>F508del</i> / <i>G551D-CFTR</i>","year":2017,"lang":"he","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":178,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources","keywords":"Ivacaftor; Medicine; Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Combination therapy; Clinical endpoint; Internal medicine; Adverse effect; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009905235,0.0005442781,0.001095765,0.0002464769,0.0003107873,0.0003552274,0.0002677936,0.000825707,0.001954991],"category_scores_gemma":[0.0008135747,0.0002813911,0.0006708589,0.0002045215,0.0003589973,0.0003365289,0.0001891733,0.0008311531,0.0002514808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003432864,"about_ca_system_score_gemma":0.0005175191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007701229,"about_ca_topic_score_gemma":0.001974099,"domain_scores_codex":[0.9995695,0.0002192206,0.00002923747,0.00008067915,0.00005077769,0.00005066295],"domain_scores_gemma":[0.9995286,0.0001038369,0.0001544315,0.0000230123,0.00004231821,0.0001477746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.8504855,0.01879397,0.0253347,0.0005867112,0.0009735507,0.0001630413,0.0001189687,0.0004070209,0.04585557,0.00006243969,0.001220115,0.05599842],"study_design_scores_gemma":[0.270962,0.63333,0.08614615,0.00008042496,0.001166355,0.0002097353,0.0001081203,0.0008759695,0.005343696,0.0000748942,0.001676021,0.00002661836],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965294,0.001999314,0.0001160786,0.0001190026,0.00005282487,0.000366729,0.0002216633,0.00001937768,0.000575582],"genre_scores_gemma":[0.9979157,0.0006140856,0.0002899361,0.0001615878,0.00007334599,0.0002811784,0.0001588135,0.000002991042,0.00050241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001954991,"threshold_uncertainty_score":0.00654012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02143986308964113,"score_gpt":0.3407033660678132,"score_spread":0.319263502978172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}