{"id":"W2754853308","doi":"10.1016/j.cardfail.2017.08.407","title":"Protein Kinase a Activation Reduces Calmodulin-Ryanodine Affinity in R176Q/+ and R2474S/+ Knock-in Mouse","year":2017,"lang":"en","type":"article","venue":"Journal of Cardiac Failure","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"","keywords":"Ryanodine receptor 2; Catecholaminergic polymorphic ventricular tachycardia; Ryanodine receptor; Calmodulin; Mutation; Medicine; Cell biology; Internal medicine; Biophysics; Calcium; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008157219,0.001696021,0.00119153,0.00163948,0.0008602975,0.0009345222,0.001740205,0.002722244,0.01891924],"category_scores_gemma":[0.0005576037,0.0009874833,0.001405062,0.0004853152,0.002134278,0.0009082612,0.0008775076,0.00321012,0.003221365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007304101,"about_ca_system_score_gemma":0.0005769083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002419453,"about_ca_topic_score_gemma":0.003403576,"domain_scores_codex":[0.9987825,0.0001301158,0.0002374336,0.0003745318,0.0002462431,0.0002292978],"domain_scores_gemma":[0.9982823,0.0002357969,0.0007183471,0.0001033871,0.00009047189,0.0005697989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005519073,0.0001379366,0.00008692538,0.00007823057,0.00003194825,0.0003913842,0.00004785478,0.0001183086,0.9972312,0.0003909433,0.0003248324,0.0006085046],"study_design_scores_gemma":[0.001314208,0.0008829807,0.007423155,0.00008229669,0.0003024578,0.003312738,0.0004104308,0.003960896,0.9711665,0.0006844726,0.0103412,0.0001185094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781362,0.001112309,0.009342172,0.001489997,0.001131423,0.0001948877,0.005164007,0.0009471207,0.002481724],"genre_scores_gemma":[0.9591424,0.001256865,0.008729255,0.000917161,0.0002898224,0.0004623352,0.002304254,0.001280826,0.02561703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01891924,"threshold_uncertainty_score":0.06329113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01159409916050239,"score_gpt":0.2676296916630013,"score_spread":0.2560355925024989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}