{"id":"W2754877908","doi":"10.1021/acs.joc.7b01959","title":"Total Synthesis of Glycinocins A–C","year":2017,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Australian Research Council; Natural Sciences and Engineering Research Council of Canada; University of Sydney","keywords":"Moiety; Total synthesis; Bacillus subtilis; Daptomycin; Staphylococcus aureus; Antimicrobial; Chemistry; Calcium; Antibiotics; Microbiology; Stereochemistry; Bacteria; Biochemistry; Biology; Organic chemistry; Vancomycin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001916572,0.0006396497,0.0003121018,0.0003894629,0.0002791606,0.0004446575,0.0003315181,0.0003000074,0.0009962398],"category_scores_gemma":[0.0002584617,0.0001422995,0.0003301958,0.0004727287,0.0002533853,0.0005025592,0.0007020098,0.0009229862,0.0006349213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003666039,"about_ca_system_score_gemma":0.0008287544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004619283,"about_ca_topic_score_gemma":0.0006346811,"domain_scores_codex":[0.9998056,0.00002590247,0.00002006629,0.00004596375,0.0000558531,0.00004664997],"domain_scores_gemma":[0.9998361,0.00002005462,0.00003201927,0.00002702961,0.00003716285,0.00004756153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002391112,0.00006863697,0.0002372233,0.0001918846,0.00002909215,0.0003696467,0.00006178108,0.000967528,0.980956,0.001592574,0.0002275902,0.01505895],"study_design_scores_gemma":[0.00005514449,0.0004684211,0.0008864272,0.00002498771,0.00004875756,0.0008118213,0.0000406904,0.001091635,0.9811108,0.0008415241,0.01458887,0.00003098563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8957399,0.00430675,0.07070394,0.0003282412,0.0002374066,0.000388202,0.003856429,0.0004032057,0.02403603],"genre_scores_gemma":[0.9475253,0.003299845,0.04200005,0.000149727,0.00002916683,0.0001656012,0.001798447,0.00008728793,0.004944501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009962398,"threshold_uncertainty_score":0.003332734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01088457477092213,"score_gpt":0.2395958679800358,"score_spread":0.2287112932091136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}