{"id":"W2754901779","doi":"10.1016/j.celrep.2017.08.062","title":"Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer Polymorphism","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre","funders":"Medical Research Council; Canadian Institutes of Health Research; Deutsche Krebshilfe; Dietmar Hopp Stiftung; Heinz Nixdorf Stiftung; Myeloma UK; Deutsche Forschungsgemeinschaft; Rosetrees Trust; Cancer Research UK; Bloodwise; Wellcome Trust; Foundation Medicine; McGill University; Bundesministerium für Bildung und Forschung; Blood Cancer UK; Multiple Myeloma Research Foundation","keywords":"Enhancer; Genetics; Biology; Allele; Transcription factor; Carcinogenesis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000145589,0.0002501499,0.0003246876,0.00009711149,0.0004444642,0.00008069652,0.0001500634,0.0001511138,0.00109496],"category_scores_gemma":[0.0002585908,0.0002159159,0.0001048196,0.00006456732,0.00009186609,0.0001548243,0.0001584199,0.0001310683,0.0004563584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002349889,"about_ca_system_score_gemma":0.0001166382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006704981,"about_ca_topic_score_gemma":0.0001169008,"domain_scores_codex":[0.997691,0.00003647638,0.0004010588,0.000690422,0.0006329028,0.0005480846],"domain_scores_gemma":[0.9970675,0.00003840074,0.0002694817,0.00152487,0.0001465126,0.0009532195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004228303,0.0005039966,0.3160196,0.00005634673,0.00008348115,0.004755154,0.0003394567,0.00000145206,0.6453136,1.347349e-7,0.02296019,0.009543779],"study_design_scores_gemma":[0.001479401,0.0004493716,0.4840177,0.00005100586,0.00006329282,0.000307776,0.00001232681,0.0003631253,0.5017944,0.00001106823,0.01126349,0.0001870342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914908,0.0005208271,0.00009601673,0.0005181214,0.0002745887,0.001021158,0.00006941317,0.00008205199,0.005926983],"genre_scores_gemma":[0.9798295,0.00009432943,0.0007402737,0.0002842934,0.000208371,0.0001360887,0.0004232353,0.00005291168,0.018231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1679981,"threshold_uncertainty_score":0.9998181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01824185097656193,"score_gpt":0.2943264266568501,"score_spread":0.2760845756802882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}