{"id":"W2755064755","doi":"10.1001/jamaneurol.2017.2107","title":"Survival End Points for Huntington Disease Trials Prior to a Motor Diagnosis","year":2017,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Allergan; AOP Orphan; Amarin Corporation; Wellcome Trust; Pfizer; Cure Huntington's Disease Initiative; Ipsen; H. Lundbeck A/S; Alnylam Pharmaceuticals; Bundesministerium für Bildung und Forschung; Teva Pharmaceutical Industries; European Huntington's Disease Network; CHDI Foundation; European Commission; Sanofi; Deutsche Forschungsgemeinschaft; GlaxoSmithKline","keywords":"Cohort; Medicine; Cohort study; Clinical trial; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007283409,0.0003090357,0.000591163,0.0001502359,0.0007460355,0.0003855906,0.001113545,0.0001184238,0.0001935104],"category_scores_gemma":[0.08196693,0.0002883342,0.0003099353,0.00007698567,0.0002318498,0.000207453,0.0004530101,0.0002064539,0.0001693796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001143226,"about_ca_system_score_gemma":0.0001136074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000219491,"about_ca_topic_score_gemma":0.00002631438,"domain_scores_codex":[0.996158,0.001138101,0.0005168269,0.001192559,0.0003383486,0.0006561568],"domain_scores_gemma":[0.9940265,0.003624732,0.0004371568,0.001250384,0.0001057332,0.0005554394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007730129,0.0008773214,0.09828093,0.0001050525,0.00002737832,0.0001834843,0.0001587714,0.0001000375,0.8470001,0.003890921,0.01186411,0.02978182],"study_design_scores_gemma":[0.002176864,0.0008309066,0.4265786,0.000008150801,0.00008011427,0.000002426947,0.000002373093,0.0001683459,0.5364762,0.00113626,0.03222999,0.0003098172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9589322,0.00001343567,0.000185774,0.03566279,0.002187818,0.001948376,0.0006844403,0.00008606335,0.0002991356],"genre_scores_gemma":[0.9803773,0.00003257395,0.0001909594,0.01675173,0.0009122107,0.001322624,0.000005155654,0.00006535282,0.0003421108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3282976,"threshold_uncertainty_score":0.9999569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09196650484374848,"score_gpt":0.3523326775631843,"score_spread":0.2603661727194359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}