{"id":"W2755078948","doi":"10.1164/rccm.201707-1323oc","title":"Weight-adjusted Intravenous Reslizumab in Severe Asthma with Inadequate Response to Fixed-Dose Subcutaneous Mepolizumab","year":2017,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":191,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Mepolizumab; Medicine; Eosinophil; Sputum; Eosinophilia; Immunology; Prednisone; Internal medicine; Asthma; Benralizumab; Gastroenterology; Placebo; Pathology; Tuberculosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007342076,0.0003774311,0.001206859,0.0005550824,0.0003475371,0.00005491716,0.0003451077,0.0001096663,0.00009303201],"category_scores_gemma":[0.00365409,0.0002501596,0.0001156425,0.0003292787,0.002205424,0.0002049857,0.00009315139,0.0007435688,0.0000069002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002167846,"about_ca_system_score_gemma":0.0007960172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001046795,"about_ca_topic_score_gemma":0.00009297637,"domain_scores_codex":[0.9967902,0.000503844,0.0008354475,0.0004240875,0.0008658041,0.0005806634],"domain_scores_gemma":[0.9961364,0.0005960568,0.0004099404,0.0006844606,0.0008066364,0.001366555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1012119,0.0003963788,0.04457277,0.0004745095,0.0001282946,0.06862476,0.004703282,0.00001460909,0.003736701,0.0003318038,0.0006681065,0.7751369],"study_design_scores_gemma":[0.0176217,0.1699812,0.6857147,0.005251761,0.0006865152,0.02043781,0.034536,0.00001329882,0.0009105276,0.0001119591,0.063774,0.0009604938],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864047,0.003215293,0.00008814667,0.008996246,0.000191458,0.0002922645,0.00001518521,0.00002197919,0.0007746966],"genre_scores_gemma":[0.9948814,0.00005073623,0.0003383042,0.003995388,0.0006226648,0.00000981331,0.000001517973,0.00005057113,0.00004962959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7741764,"threshold_uncertainty_score":0.9999951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01514342245078652,"score_gpt":0.3017885606380014,"score_spread":0.2866451381872148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}