{"id":"W2755190636","doi":"10.1016/j.str.2017.08.005","title":"Structural Insight into BLM Recognition by TopBP1","year":2017,"lang":"en","type":"article","venue":"Structure","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; Canadian Institutes of Health Research; U.S. Bureau of Land Management; Cancer Research UK; Canadian Light Source","keywords":"Helicase; DNA; Biology; Binding site; Protein–protein interaction; Cell biology; DNA replication; DNA-binding protein; Biophysics; Chemistry; Genetics; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003565811,0.0001621577,0.0001115866,0.00001715027,0.000310353,0.00009480418,0.0003512419,0.000238512,0.000178815],"category_scores_gemma":[0.00009112098,0.0001426372,0.00006408079,0.00001659441,0.00008152731,0.0000101636,0.0001623213,0.0001152245,0.00001273871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001319254,"about_ca_system_score_gemma":0.00002785033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004008931,"about_ca_topic_score_gemma":0.00009255317,"domain_scores_codex":[0.9992065,0.00002568514,0.0001161541,0.00034336,0.0001179879,0.0001903368],"domain_scores_gemma":[0.9990835,0.000002179322,0.0001118783,0.0006619573,0.00006353956,0.00007695501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003068633,0.000002600285,0.0004477071,0.00001033342,0.00002707067,0.000002902017,0.00007584435,8.155598e-7,0.9717233,0.00006336056,0.003205554,0.02440986],"study_design_scores_gemma":[0.0004125801,0.0001151375,0.00207528,0.000007346468,0.0000146018,0.00002427553,0.00002143881,0.00001992133,0.9532112,0.007518215,0.0363427,0.0002372746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961513,0.0002506043,0.00008279106,0.0001737005,0.0006091704,0.0001282312,0.0001090863,0.00002204959,0.002473058],"genre_scores_gemma":[0.9961091,0.00002192271,0.001858522,0.0002585791,0.0003976221,0.000005374311,0.0005223534,0.00002371816,0.0008028328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03313715,"threshold_uncertainty_score":0.5816575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00810371319501362,"score_gpt":0.2439511558457699,"score_spread":0.2358474426507563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}