{"id":"W2755190636","doi":"10.1016/j.str.2017.08.005","title":"Structural Insight into BLM Recognition by TopBP1","year":2017,"lang":"en","type":"article","venue":"Structure","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; Canadian Institutes of Health Research; U.S. Bureau of Land Management; Cancer Research UK; Canadian Light Source","keywords":"Helicase; DNA; Biology; Binding site; Protein–protein interaction; Cell biology; DNA replication; DNA-binding protein; Biophysics; Chemistry; Genetics; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002382512,0.0004816013,0.0004428471,0.0001919209,0.0005112889,0.0007076359,0.0006901973,0.0007327854,0.003733885],"category_scores_gemma":[0.0002588962,0.0002681869,0.0003054424,0.000176621,0.0003206261,0.0006391339,0.0003063129,0.001503364,0.001346466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00110681,"about_ca_system_score_gemma":0.0005100379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001052907,"about_ca_topic_score_gemma":0.00107087,"domain_scores_codex":[0.9999272,0.000009463078,0.00000435506,0.00001541761,0.00002393238,0.00001959352],"domain_scores_gemma":[0.9999224,0.0000170036,0.00001677632,0.000007815313,0.00001173647,0.0000243263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004725929,0.0001153835,0.0008537344,0.0003048387,0.00002365718,0.0009046372,0.0001203336,0.004171378,0.9716747,0.01055894,0.00147809,0.009321731],"study_design_scores_gemma":[0.00008638833,0.0003274349,0.006225277,0.00006366414,0.00005142577,0.001487898,0.0003441817,0.03991768,0.9147062,0.008218055,0.02851112,0.00006060702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9254313,0.009027591,0.04662362,0.004937163,0.0004633285,0.00005869694,0.00107628,0.0009199161,0.011462],"genre_scores_gemma":[0.9837862,0.002207777,0.008841679,0.0003646387,0.00004414599,0.00001477803,0.0007387703,0.00003652732,0.003965614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003733885,"threshold_uncertainty_score":0.01249105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00810371319501362,"score_gpt":0.2439511558457699,"score_spread":0.2358474426507563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}