{"id":"W2755229746","doi":"10.1136/annrheumdis-2017-eular.3840","title":"AB0785 Consistent safety profile with up to 4 years of apremilast treatment: analysis of data from 1493 patients with psoriatic arthritis in 3 large, phase iii, long-term studies","year":2017,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital","funders":"Momenta Pharmaceuticals; Janssen Pharmaceuticals; Genentech; Horizon Pharma; AstraZeneca; Celgene; Amgen; Pfizer; Eli Lilly and Company","keywords":"Apremilast; Medicine; Psoriatic arthritis; Adverse effect; Placebo; Nausea; Internal medicine; Upper respiratory tract infection; Randomized controlled trial; Tolerability; Psoriasis; Arthritis; Gastroenterology; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0109124,0.0009176391,0.003405601,0.0006143581,0.0005775176,0.001535214,0.0008029527,0.0009784232,0.001771371],"category_scores_gemma":[0.006205152,0.0005471963,0.004965929,0.001465328,0.0009208693,0.001377374,0.0005039532,0.001900435,0.0004314493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005776299,"about_ca_system_score_gemma":0.0009417022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000503487,"about_ca_topic_score_gemma":0.001364043,"domain_scores_codex":[0.994825,0.002994859,0.0005812135,0.0006631691,0.0007202887,0.0002154919],"domain_scores_gemma":[0.9904103,0.004965931,0.00247305,0.001204842,0.0005364994,0.000409374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6046138,0.003173641,0.1752494,0.004210588,0.06855889,0.0005693087,0.0004384212,0.003080802,0.02170182,0.0002526919,0.003697742,0.1144529],"study_design_scores_gemma":[0.1708625,0.09869955,0.6659284,0.0003524224,0.04685542,0.00225195,0.0002836733,0.001794867,0.004398245,0.0005174445,0.007846299,0.0002091496],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.965413,0.02709419,0.00133404,0.0003052834,0.00008156282,0.0004735755,0.003736001,0.0000906694,0.00147156],"genre_scores_gemma":[0.990571,0.003002234,0.0008185243,0.0004450991,0.00009569331,0.0002254859,0.004457681,0.0000306257,0.0003538103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0109124,"threshold_uncertainty_score":0.05771101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07738426380436773,"score_gpt":0.3734743654847418,"score_spread":0.296090101680374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}