{"id":"W2755241910","doi":"10.1124/jpet.117.243253","title":"Novel Pharmacological Probes Reveal ABHD5 as a Locus of Lipolysis Control in White and Brown Adipocytes","year":2017,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; McMaster University; National Institutes of Health; Wayne State University","keywords":"Lipolysis; Adipose triglyceride lipase; Adipocyte; Hormone-sensitive lipase; Perilipin; Catabolism; Internal medicine; Endocrinology; Lipid droplet; Biology; Adipose tissue; Protein kinase A; Chemistry; Phosphorylation; Cell biology; Metabolism; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002012398,0.0002598547,0.0002071482,0.0002000489,0.0003961892,0.000428263,0.0005017007,0.0003911651,0.003318368],"category_scores_gemma":[0.0001445259,0.0001986136,0.000239458,0.0001246819,0.0004449291,0.0004293648,0.0003574022,0.0008750703,0.0003301502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004773028,"about_ca_system_score_gemma":0.0002652867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006643479,"about_ca_topic_score_gemma":0.001295073,"domain_scores_codex":[0.9999033,0.0000125261,0.000005521607,0.00002766128,0.00001841048,0.00003265271],"domain_scores_gemma":[0.999946,0.00001413944,0.00001062852,0.000006872451,0.000005498008,0.0000168627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002433098,0.00002092312,0.0001139568,0.00002844898,0.000005676491,0.00004031545,0.00001609991,0.0001024528,0.9956632,0.001721293,0.0000739368,0.001970266],"study_design_scores_gemma":[0.00004028391,0.0001987756,0.001638672,0.000006412415,0.00001667545,0.0001404091,0.00005922243,0.0009559775,0.993715,0.0006453415,0.002576921,0.000006260856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9593513,0.002611967,0.02874319,0.001154533,0.0002098411,0.00008202581,0.0007463326,0.000144816,0.006955892],"genre_scores_gemma":[0.9832017,0.0009226085,0.01054907,0.0003182217,0.00003861565,0.00004917543,0.0003800883,0.00002977275,0.004510849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003318368,"threshold_uncertainty_score":0.01110107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01836854082714342,"score_gpt":0.3229306558246454,"score_spread":0.304562114997502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}