{"id":"W2755320026","doi":"10.1200/jco.2018.36.4_suppl.tps192","title":"CheckMate 649: A randomized, multicenter, open-label, phase III study of nivolumab (NIVO) + ipilimumab (IPI) or nivo + chemotherapy (CTX) versus CTX alone in patients with previously untreated advanced (Adv) gastric (G) or gastroesophageal junction (GEJ) cancer.","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Gastric Cancer Management and Outcomes","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre intégré universitaire de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec","funders":"","keywords":"Medicine; Nivolumab; Ipilimumab; Internal medicine; Cancer; Oncology; Chemotherapy; Phases of clinical research; Gastroenterology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001223701,0.001307259,0.001235521,0.0003716156,0.0002899015,0.00104017,0.0007909133,0.001298964,0.006313144],"category_scores_gemma":[0.000892872,0.0005131339,0.001269023,0.0002837105,0.0006746607,0.0007329412,0.0003262006,0.002475325,0.001008445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006638406,"about_ca_system_score_gemma":0.000890827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009135869,"about_ca_topic_score_gemma":0.002776252,"domain_scores_codex":[0.9997844,0.0001176673,0.000009504605,0.00003559588,0.00001805929,0.00003469896],"domain_scores_gemma":[0.9995827,0.00008697835,0.0001115323,0.00002672338,0.0000216434,0.0001703174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9221928,0.02476051,0.001706152,0.0008360834,0.00126218,0.0000838576,0.00008470372,0.001013473,0.01370462,0.000331648,0.003284335,0.03073971],"study_design_scores_gemma":[0.9022672,0.09138884,0.002395466,0.00003455365,0.0004492406,0.00005886637,0.00002128342,0.000726481,0.0009556309,0.0001391381,0.001546606,0.00001669698],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855961,0.003333342,0.0008784168,0.0007804647,0.0004893854,0.003539394,0.002156473,0.0002373455,0.002989099],"genre_scores_gemma":[0.9825732,0.002087198,0.001810203,0.001584112,0.0002841061,0.003336517,0.002575427,0.00004227078,0.005706847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006313144,"threshold_uncertainty_score":0.02111959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09015254805863154,"score_gpt":0.4607542864208127,"score_spread":0.3706017383621811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}