{"id":"W2755380079","doi":"10.1016/j.bpj.2017.08.047","title":"Functional Validation of Heteromeric Kainate Receptor Models","year":2017,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research; Medical Research Council; Alfred Benzon Foundation","keywords":"Homomeric; Kainate receptor; Biophysics; Ion channel; Receptor; Chemistry; Xenopus; Gating; Dimer; Biochemistry; Biology; Glutamate receptor; AMPA receptor; Protein subunit","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001799738,0.000096099,0.0001465376,0.00009285827,0.0008257098,0.0001740614,0.0006207831,0.00003314319,0.0001444853],"category_scores_gemma":[0.0003228538,0.00007670724,0.000113987,0.0001155593,0.0005343532,0.0008334417,0.0001521386,0.0003546638,0.0001313931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001937587,"about_ca_system_score_gemma":0.0000596071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001363227,"about_ca_topic_score_gemma":1.656727e-8,"domain_scores_codex":[0.9985592,0.0001679964,0.0001988485,0.0002592584,0.0005383862,0.0002762514],"domain_scores_gemma":[0.9991413,0.0001120517,0.0002660353,0.0002448888,0.0000815781,0.0001541339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009010497,0.0001410666,0.0000711159,0.000003762912,0.000002052877,0.00003117754,0.00001486386,0.0001201952,0.9974176,0.0005844198,0.0005058673,0.001017735],"study_design_scores_gemma":[0.0003865381,0.0002179445,0.001434925,0.000006359438,0.000004993364,0.00007706978,0.000002344969,0.002064692,0.9945888,0.0009445292,0.0001986179,0.00007316688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971041,0.000001420395,0.0003964404,0.0009374255,0.0009279735,0.00007381386,0.000007799214,0.00001349096,0.0005375097],"genre_scores_gemma":[0.9989042,0.00007687798,0.00002173695,0.0002329701,0.0003119322,0.000003858368,1.671774e-7,0.00001017941,0.0004380918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002828819,"threshold_uncertainty_score":0.6350775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1307324707764749,"score_gpt":0.363479395992504,"score_spread":0.2327469252160291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}