{"id":"W2755380079","doi":"10.1016/j.bpj.2017.08.047","title":"Functional Validation of Heteromeric Kainate Receptor Models","year":2017,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Biotechnology and Biological Sciences Research Council; Engineering and Physical Sciences Research Council; Canadian Institutes of Health Research; Medical Research Council; Alfred Benzon Foundation","keywords":"Homomeric; Kainate receptor; Biophysics; Ion channel; Receptor; Chemistry; Xenopus; Gating; Dimer; Biochemistry; Biology; Glutamate receptor; AMPA receptor; Protein subunit","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00112344,0.0007733414,0.0006936471,0.0003739421,0.0006471848,0.001278884,0.001623638,0.001238343,0.002958024],"category_scores_gemma":[0.001143145,0.0002790459,0.0005533475,0.000254434,0.0005933464,0.001046502,0.0004476021,0.001795212,0.001737299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001038668,"about_ca_system_score_gemma":0.0004770069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001041249,"about_ca_topic_score_gemma":0.0007768476,"domain_scores_codex":[0.9993432,0.0001311851,0.00006377984,0.0001304757,0.0002421132,0.00008933892],"domain_scores_gemma":[0.9994352,0.0001333557,0.00007527947,0.0001220456,0.0001643617,0.00006961476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004855185,0.0002244734,0.0001695316,0.0000850826,0.00004279659,0.0001198364,0.00006530269,0.001783808,0.9915665,0.002648356,0.0004459466,0.002363004],"study_design_scores_gemma":[0.0001701306,0.0007219242,0.0009376243,0.00002188346,0.0001214194,0.0005968745,0.0001374624,0.05075276,0.936737,0.001237801,0.00852478,0.00004033495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665235,0.0009563928,0.02639912,0.0006334309,0.0004011269,0.0001064647,0.001138889,0.0003765081,0.003464673],"genre_scores_gemma":[0.9840446,0.0007225481,0.01035257,0.0001483681,0.00003970639,0.0001047921,0.001584694,0.0002452721,0.002757591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002958024,"threshold_uncertainty_score":0.009895623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1307324707764749,"score_gpt":0.363479395992504,"score_spread":0.2327469252160291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}