{"id":"W2755382968","doi":"10.14814/phy2.13395","title":"Depletion of the mRNA translation initiation inhibitor, programmed cell death protein 4 (PDCD4), impairs L6 myotube formation","year":2017,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada; York University","keywords":"mTORC1; P70-S6 Kinase 1; Programmed cell death; Cell biology; Poly ADP ribose polymerase; Ubiquitin ligase; Biology; Myogenesis; Apoptosis; Myocyte; C2C12; Protein degradation; Downregulation and upregulation; Chemistry; Molecular biology; Signal transduction; PI3K/AKT/mTOR pathway; Ubiquitin; Biochemistry; Polymerase; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002138836,0.0001380278,0.0001507179,0.00001537863,0.0003037049,0.00002140501,0.0001641287,0.0002071786,0.00001249184],"category_scores_gemma":[0.0002690065,0.00009247811,0.000160361,0.0000356566,0.0001423474,0.0000248041,0.00008660113,0.0001056081,0.000001488371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009816106,"about_ca_system_score_gemma":0.0000426337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003392005,"about_ca_topic_score_gemma":0.00001798726,"domain_scores_codex":[0.9989296,0.0001071737,0.000346551,0.0002870749,0.000141487,0.0001881349],"domain_scores_gemma":[0.9986963,0.000008413474,0.0006003252,0.00055672,0.00009566591,0.00004263305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001319903,0.0001482814,0.004658008,0.0000424917,0.000009987612,0.000001485519,0.00003437727,0.00008513503,0.9920436,0.0000476884,0.0001176842,0.002679273],"study_design_scores_gemma":[0.0004600129,0.000489334,0.3431602,0.00002988045,0.00001823476,0.000007735945,0.00002826219,0.0002136344,0.6495415,0.005152263,0.0007206984,0.000178242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972804,0.00008716471,0.0004627383,0.0001428467,0.0001227616,0.0006535489,0.000004084327,0.00001665792,0.001229775],"genre_scores_gemma":[0.9992487,0.00002973416,0.0002212343,0.00006645363,0.000112336,0.0001126643,0.0001751817,0.000008765083,0.0000249479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3425021,"threshold_uncertainty_score":0.3771148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02964790027559742,"score_gpt":0.268963026400868,"score_spread":0.2393151261252706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}