{"id":"W2755382968","doi":"10.14814/phy2.13395","title":"Depletion of the mRNA translation initiation inhibitor, programmed cell death protein 4 (PDCD4), impairs L6 myotube formation","year":2017,"lang":"en","type":"article","venue":"Physiological Reports","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada; York University","keywords":"mTORC1; P70-S6 Kinase 1; Programmed cell death; Cell biology; Poly ADP ribose polymerase; Ubiquitin ligase; Biology; Myogenesis; Apoptosis; Myocyte; C2C12; Protein degradation; Downregulation and upregulation; Chemistry; Molecular biology; Signal transduction; PI3K/AKT/mTOR pathway; Ubiquitin; Biochemistry; Polymerase; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001685471,0.0003786133,0.0004282397,0.0003532311,0.0002292792,0.0003429498,0.0003329529,0.0003926449,0.001611123],"category_scores_gemma":[0.000116203,0.0002235299,0.0003255717,0.0001984726,0.000389192,0.0002521168,0.0002621893,0.000688763,0.0007485732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000531668,"about_ca_system_score_gemma":0.0003056178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001385824,"about_ca_topic_score_gemma":0.001859366,"domain_scores_codex":[0.9997852,0.00002973061,0.00003520578,0.00004758424,0.00005590306,0.00004635415],"domain_scores_gemma":[0.9997882,0.0000364567,0.00005549602,0.00001977651,0.00001683308,0.00008325292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001692995,0.00003527403,0.000185783,0.00002582831,0.000005008573,0.000027314,0.00001266182,0.00003619027,0.9988827,0.0000341651,0.00002876299,0.0005570182],"study_design_scores_gemma":[0.00001478981,0.0003532744,0.003572252,0.000003997545,0.000008026669,0.00008882397,0.00002920969,0.0006443561,0.9944655,0.00001946303,0.0007973451,0.000002963584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944717,0.001636497,0.001625035,0.0001275814,0.00003733496,0.00002664064,0.0006409787,0.0001458505,0.001288573],"genre_scores_gemma":[0.9882393,0.001077553,0.003178706,0.00008139815,0.000008678438,0.0000743933,0.0009113958,0.00005190038,0.00637657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001611123,"threshold_uncertainty_score":0.00538969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02964790027559742,"score_gpt":0.268963026400868,"score_spread":0.2393151261252706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}