{"id":"W2755384370","doi":"10.1016/j.euf.2017.08.003","title":"Obstacles in Renal Regenerative Medicine: Metabolic and Epigenetic Parallels Between Cellular Reprogramming and Kidney Cancer Oncogenesis","year":2017,"lang":"en","type":"review","venue":"European Urology Focus","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Université Laval; Hôtel-Dieu de Québec; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Kidney Foundation of Canada; Kidney Foundation of Central Pennsylvania","keywords":"Medicine; Reprogramming; Carcinogenesis; Epigenetics; Regenerative medicine; Kidney cancer; Epigenesis; Kidney; Cancer; Bioinformatics; Cancer research; Internal medicine; Genetics; DNA methylation; Stem cell; Biology; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008200097,0.0005755364,0.001167076,0.00129299,0.0003145438,0.001390016,0.0007338057,0.001328927,0.003060529],"category_scores_gemma":[0.0009171545,0.0001914034,0.0004081085,0.001488655,0.0007708913,0.001481397,0.000944,0.002148851,0.00105082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007889261,"about_ca_system_score_gemma":0.001732033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009632413,"about_ca_topic_score_gemma":0.002516001,"domain_scores_codex":[0.9997922,0.00003561599,0.0000232873,0.00003328109,0.00008494662,0.00003071078],"domain_scores_gemma":[0.9995525,0.0002184593,0.00004622573,0.00001339027,0.0001253978,0.00004397047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001143264,0.00005403006,0.0004251897,0.01224027,0.00010694,0.0003311763,0.00009290856,0.0005604575,0.002829863,0.01401106,0.04662441,0.9226093],"study_design_scores_gemma":[0.00001023611,0.00004176733,0.0006011799,0.00205577,0.00009309578,0.0008634601,0.0001141881,0.0001081096,0.0007636974,0.005465752,0.9898624,0.00002024652],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001127146,0.9978156,0.0001912953,0.0008459056,0.000275672,0.000001839462,0.00001761968,0.000007291041,0.0007320213],"genre_scores_gemma":[0.0009346736,0.9976907,0.0001714468,0.0004139611,0.0002899025,0.000002870255,0.00002513223,0.000001580186,0.0004697422],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003060529,"threshold_uncertainty_score":0.01023847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05441172613461227,"score_gpt":0.3373909179126796,"score_spread":0.2829791917780673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}