{"id":"W2755434770","doi":"10.1097/wco.0000000000000488","title":"Revisiting the concept of amyotrophic lateral sclerosis as a multisystems disorder of limited phenotypic expression","year":2017,"lang":"en","type":"review","venue":"Current Opinion in Neurology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Amyotrophic lateral sclerosis; Neuropathology; Neuroscience; Phenotype; Disease; Pathogenesis; Motor neuron; Lower motor neuron; C9orf72; Frontotemporal dementia; Motor system; Biology; Neurodegeneration; Genetic heterogeneity; Medicine; Pathology; Genetics; Gene; Spinal cord","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001169588,0.0009814098,0.001810296,0.002770666,0.0004100927,0.001657903,0.001193599,0.001721171,0.003035886],"category_scores_gemma":[0.002288648,0.0002447685,0.0005728337,0.002506907,0.001225011,0.003310569,0.001245935,0.002801144,0.001371324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001007436,"about_ca_system_score_gemma":0.003032912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001277496,"about_ca_topic_score_gemma":0.001999157,"domain_scores_codex":[0.9995818,0.00009667611,0.00008788252,0.00007079063,0.0001318339,0.00003108999],"domain_scores_gemma":[0.9988175,0.0005940333,0.0001766734,0.00003160628,0.0003033466,0.00007668781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008427803,0.00004091585,0.0004375017,0.05007783,0.0002058296,0.0009486335,0.0004500243,0.0003203452,0.001605674,0.01507893,0.1122585,0.8184915],"study_design_scores_gemma":[0.0000107412,0.00004748002,0.0007305927,0.01260244,0.0001753272,0.003525878,0.0002644735,0.0000598041,0.000153514,0.00422573,0.9781827,0.00002142373],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006646003,0.9974438,0.0000921548,0.001089188,0.0007448696,0.000003093977,0.000009663587,0.000005348835,0.0005454553],"genre_scores_gemma":[0.0006993447,0.9971117,0.0001348004,0.0009575224,0.0008047601,0.000004907477,0.00001919262,0.000002367779,0.0002654414],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003035886,"threshold_uncertainty_score":0.01015604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2343432615774494,"score_gpt":0.4375419530079696,"score_spread":0.2031986914305202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}