{"id":"W2755527366","doi":"10.1371/journal.ppat.1006616","title":"HIF-1α is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis","year":2017,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Institute of Infection and Immunity; Natural Sciences and Engineering Research Council of Canada; Fonds de Recherche du Québec - Santé; Universitaire Stichting; Canada Foundation for Innovation; Institut national de la recherche scientifique","keywords":"Myelopoiesis; Leishmania donovani; Visceral leishmaniasis; Myeloid-derived Suppressor Cell; Myeloid; Immunology; Immunosuppression; Bone marrow; Biology; Spleen; Leishmaniasis; Haematopoiesis; Cell biology; Cancer research; Suppressor; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001138682,0.0001389756,0.0001222642,0.0001336242,0.0001436682,0.0001633679,0.00008103839,0.0001418037,0.0010582],"category_scores_gemma":[0.00007117201,0.00006654624,0.0001003387,0.00008343738,0.0001775854,0.00009801842,0.0001241981,0.0002621683,0.0001792741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001800234,"about_ca_system_score_gemma":0.0001324677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002209006,"about_ca_topic_score_gemma":0.0002254752,"domain_scores_codex":[0.9999324,0.00001206557,0.000003822914,0.0000120676,0.00001312584,0.00002655841],"domain_scores_gemma":[0.9999497,0.000004435867,0.00001454845,0.000003734502,0.000008362275,0.00001928044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002233649,0.00001713434,0.0009241047,0.00004665922,0.000003077459,0.0001149422,0.00002079362,0.00007439141,0.9958128,0.0001760711,0.0001525494,0.002433964],"study_design_scores_gemma":[0.00003339844,0.0004169157,0.03299823,0.00002167858,0.00001905237,0.0008310097,0.0001038721,0.0008796602,0.9527352,0.0002782942,0.0116764,0.000006292707],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875336,0.006243763,0.003129829,0.0003202991,0.00006764091,0.00002806563,0.0005507457,0.00008518234,0.002040831],"genre_scores_gemma":[0.997424,0.0007583859,0.000402287,0.00004617104,0.00001747177,0.00001185783,0.0002316701,0.000004968955,0.00110319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0010582,"threshold_uncertainty_score":0.003539979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01877268078811359,"score_gpt":0.219463413826173,"score_spread":0.2006907330380594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}