{"id":"W2755527366","doi":"10.1371/journal.ppat.1006616","title":"HIF-1α is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis","year":2017,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Institute of Infection and Immunity; Natural Sciences and Engineering Research Council of Canada; Fonds de Recherche du Québec - Santé; Universitaire Stichting; Canada Foundation for Innovation; Institut national de la recherche scientifique","keywords":"Myelopoiesis; Leishmania donovani; Visceral leishmaniasis; Myeloid-derived Suppressor Cell; Myeloid; Immunology; Immunosuppression; Bone marrow; Biology; Spleen; Leishmaniasis; Haematopoiesis; Cell biology; Cancer research; Suppressor; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003349223,0.0002563082,0.0004454295,0.00008238791,0.0009021623,0.00006087677,0.0004914473,0.0002735133,0.0001718764],"category_scores_gemma":[0.0001366727,0.0002190231,0.0001353759,0.00006202501,0.0005150224,0.0001974366,0.0004957337,0.0005295336,0.00002688073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007650473,"about_ca_system_score_gemma":0.00003874578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005674493,"about_ca_topic_score_gemma":0.0001801314,"domain_scores_codex":[0.9983435,0.0002423765,0.0003687421,0.0004476992,0.00006557675,0.0005321674],"domain_scores_gemma":[0.9983901,0.0001556248,0.0005021052,0.0008528849,0.00007716103,0.00002216075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009772235,0.0001164994,0.01911102,0.0001087238,0.0001507068,0.000009556717,0.003735546,0.000006394926,0.9760819,0.000008755565,0.00008952199,0.0004836496],"study_design_scores_gemma":[0.0008834469,0.00003212138,0.1996549,0.0001196353,0.0000704719,0.00002805968,0.0002190672,0.00002886872,0.7986559,0.00001474821,0.0001046262,0.0001881146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977652,0.0005623535,0.000005865229,0.0003046306,0.0005277441,0.0003287987,0.0001763693,0.00002839512,0.0003005945],"genre_scores_gemma":[0.9989471,0.00006650106,0.0002435398,0.00006565906,0.0000511134,0.00002156848,0.000005119398,0.00003567188,0.0005637268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1805439,"threshold_uncertainty_score":0.8931501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01877268078811359,"score_gpt":0.219463413826173,"score_spread":0.2006907330380594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}